Risk factors and type of dementia: Vascular or Alzheimer?
Risk factors and type of dementia: Vascular or Alzheimer?
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DOI：
10.1016/j.archger.2007.06.005
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发表时间：
2008-07-01
影响因子：
4
通讯作者：
Ariogul, Servet
中科院分区：
文献类型：
--
作者：
Cankurtaran, Mustafa;Yavuz, Burcu Balam;Ariogul, Servet
对抗阿尔茨海默病（AD）的最有效策略是预防临床显著症状的发作。确定临床特征，危险因素和认知储备指数将有助于实现这一目标。本研究的目的是确定老年人AD和血管性痴呆（VD）的危险因素，并强调在早期诊断中改变危险因素的重要性。共有1436例患者（平均年龄= 72.7 ± 6.9岁，34.2%为男性）入组本研究。经全面的老年学和认知功能评估后，将患者分为AD组（n = 203）、VD组（n = 73）和正常认知状态（NCS）组（n = 1160）。对33个可能相关的因素进行了检查，包括人口统计学特征、共存疾病和实验室参数。结果显示，女性、高龄、抑郁、维生素补充剂摄入是AD的独立相关因素，而抑郁、低密度脂蛋白胆固醇（LDL-C）是VD的独立相关因素。对于每一位因任何原因入院的老年患者，都应进行认知评估，确定危险因素，并对高危患者进行仔细随访。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
The most efficient strategy for combating Alzheimer's disease (AD) is to prevent the onset of clinically significant symptoms. Determining the clinical characteristics, risk factors, and indices of cognitive reserve would help in achieving this goal. The aim of this study was to determine the risk factors for AD and vascular dementia (VD) in the elderly and to highlight the importance of risk factor modification in the early diagnosis. Consecutive 1436 patients (mean age = 72.7 +/- 6.9 years, 34.2% male) were enrolled in the study. After a comprehensive geriatric and cognitive assessment, patients were grouped as AD group (n = 203), VD, group (n = 73) and normal cognitive status (NCS) group (n = 1160). Thirty-three possibly related factors including demographic characteristics, coexisting diseases and laboratory parameters were examined. The results revealed that female sex, advanced age, depression, and intake of vitamin supplements were independent related factors for AD; whereas depression and low-density lipoprotein-cholesterol (LDL-C) were independent related factors for VD. For every geriatric patient admitted for any reason, cognitive assessment should be performed, risk factors should be determined and the patients at high risk should be followed up carefully. (C) 2007 Elsevier Ireland Ltd. All rights reserved.