A nanohybrid of Prussian blue supported by boracic acid-modified g-C3N4 for Raman recognition of cell surface sialic acid and photothermal/photodynamic therapy
A nanohybrid of Prussian blue supported by boracic acid-modified g-C3N4 for Raman recognition of cell surface sialic acid and photothermal/photodynamic therapy
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由硼酸修饰的 g-C3N4 支持的普鲁士蓝纳米杂化物，用于细胞表面唾液酸的拉曼识别和光热/光动力治疗
DOI：
10.1016/j.colsurfb.2022.112490
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发表时间：
2022-04-08
影响因子：
5.8
通讯作者：
Xu, Zhang-Run
中科院分区：
文献类型：
--
作者：
Wang, Ya-Ning;Zhang, Wen-Shu;Xu, Zhang-Run
诊断准确、治疗有效的纳米诊断平台为肿瘤治疗展示了光明的前景。本文中，开发了一种新的硼酸修饰的石墨碳氮化物和普鲁士蓝纳米杂化物（PB@B-g-C3 N4），其在近红外区域提供唾液酸靶向的拉曼识别和协同光热/光动力治疗。由于硼酸和唾液酸之间的特异性相互作用以及PB在2157 cm（-1）处的拉曼响应，纳米杂化物对于检测肿瘤细胞上过表达的唾液酸表现出高特异性和拉曼灵敏度。此外，由于PB @ B-g-C3 N4的吸收增强，在808 nm激光照射下，PB @ B-g-C3 N4的光热转换效率高达47.0%。PB@B-g-C3 N4也具有优异的光动力学活性，这归因于PB的能量转移（I型）和PB与B-g-C3 N4之间的电子转移（II型）。这种用于癌症标志物的拉曼识别和协同光热/光动力疗法的纳米治疗诊断剂对于开发高效的治疗诊断纳米平台具有巨大的潜力。
Theranostic nanoplatforms with accurate diagnosis and effective therapy show a bright prospect for tumor treatments. Herein, a novel boracic acid-modified graphite carbon nitride and Prussian blue nanohybrid (PB@B-g-C3N4) was developed, which provides sialic acid-targeted Raman recognition and synergistic photothermal/ photodynamic therapy in the near-infrared region. Owing to the specific interaction between boracic acid and sialic acid and Raman response at 2157 cm(-1) of PB, the nanohybrids exhibit high specificity and Raman sensitivity for detection of the overexpressed sialic acid on tumor cells. Moreover, the photothermal conversion efficiency of PB@B-g-C3N4 is as high as 47.0% with 808 nm laser irradiation due to the enhanced absorbance of PB@B-g-C3N4. PB@B-g-C3N4 also possesses excellent photodynamic activity, which is attributed to the energy transfer of PB (type I) and electron transfer between PB and B-g-C3N4 (type II). This nanotheranostic agent for Raman recognition of cancer markers and synergistic photothermal/photodynamic therapy holds great potential for the development of efficient theranostic nanoplatforms.