Proteins of the same fold and unrelated sequences have similar amino acid composition
Proteins of the same fold and unrelated sequences have similar amino acid composition
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DOI：
10.1002/prot.20964
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发表时间：
2006-07-01
影响因子：
2.9
通讯作者：
Margalit, Hanah
中科院分区：
文献类型：
--
作者：
Ofran, Yanay;Margalit, Hanah
已经确定蛋白质的氨基酸组成与其结构类别（即，α、β、α + β或α/β）。一些研究甚至显示了氨基酸组成在预测蛋白质二级结构类别方面的力量。在这里，我们表明，氨基酸组成的显着相似性不仅存在于同一类蛋白质之间，但即使在相同的折叠蛋白质之间。为了测试对这种现象的生物学解释，我们分析了一组结构相似但序列不同的蛋白质。基于这一分析，我们认为，特定的残基参与分子内相互作用可能占这种令人惊讶的组合物和结构之间的关系。
It is well established that there is a relationship between the amino acid composition of a protein and its structural class (i.e., alpha, beta, alpha + beta, or alpha/beta). Several studies have even shown the power of amino acid composition in predicting the secondary structure class of a protein. Herein, we show that significant similarity in amino acid composition exists not only between proteins of the same class, but even between proteins of the same fold. To test conjectural explanations for this phenomenon, we analyzed a set of structurally similar proteins that are dissimilar in sequence. Based on this analysis, we suggest that specific residues that are involved in intramolecular interactions may account for this surprising relationship between composition and structure.