Functional diversity of long non-coding RNAs in immune regulation.
Functional diversity of long non-coding RNAs in immune regulation.
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DOI：
10.1016/j.gendis.2016.01.004
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发表时间：
2016-03
期刊：
影响因子：
6.8
通讯作者：
Tan, Xiao-Di
中科院分区：
文献类型：
--
作者：
Geng, Hua;Tan, Xiao-Di
基因表达的精确动态调控是免疫的一个关键特征。近年来，转录组图谱分析的快速进展使人们认识到长链非编码RNA（lncRNAs）是基因调控环境的一个新增层面。在免疫系统中，人们发现lncRNAs在免疫细胞（包括单核细胞、巨噬细胞、树突状细胞、中性粒细胞、T细胞和B细胞）的发育、分化和激活过程中广泛表达。然而，免疫相关lncRNAs的功能重要性才刚刚开始被阐明。在这篇综述中，我们讨论了lncRNAs在免疫调控方面的最新知识。
Precise and dynamic regulation of gene expression is a key feature of immunity. In recent years, rapid advances in transcriptome profiling analysis have led to recognize long non-coding RNAs (lncRNAs) as an additional layer of gene regulation context. In the immune system, lncRNAs are found to be widely expressed in immune cells including monocytes, macrophages, dendritic cells (DC), neutrophils, T cells and B cells during their development, differentiation and activation. However, the functional importance of immune-related lncRNAs is just emerging to be characterized. In this review, we discuss the up-to-date knowledge of lncRNAs in immune regulation.