The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer
The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer
复制标题
DOI：
10.1007/s00432-023-05362-1
复制
发表时间：
2023-09-16
影响因子：
3.6
通讯作者：
Chen，Youpeng
中科院分区：
文献类型：
--
作者：
Zhang，Yi;Xu，Haifeng;Chen，Youpeng
背景和目的FKBP1A是一种编码FK506结合蛋白1A的基因，在癌症的进展和预后中起着重要作用。本研究旨在全面探讨FKBP1A在癌症中的多方面作用，重点关注其差异表达模式，预后意义，遗传改变以及与肿瘤微环境的相关性。方法和结果使用大规模数据集，包括GTEx，TCGA，HPA和cBioPortal，我们分析了FKBP1A在正常组织和各种癌症类型中的表达。我们的研究结果表明，FKBP1A在大多数人类癌症中表现出异常上调，使其成为恶性肿瘤的潜在生物标志物。此外，FKBP1A表达与几种癌症的不良总生存期、疾病特异性生存期、无病间期和无进展间期相关，表明其预后意义。遗传变异分析显示FKBP1A基因扩增普遍存在，尤其在卵巢癌中。此外，FKBP1A表达与肿瘤突变负荷和微卫星不稳定性相关，突出了其在肿瘤免疫应答中的潜在参与。值得注意的是，FKBP1A表达与基质和免疫细胞评分呈正相关，表明其在塑造肿瘤微环境中的作用。此外，根据功能富集分析，在肺腺癌中的实验验证证实了FKBP1A的作用，通过调节EGFR信号的细胞凋亡，这是一致的药物敏感性分析在一定程度上conclusionIn conclusion，FKBP1A在癌症中表现出差异表达，作为一个预后指标，经历遗传改变，并影响肿瘤免疫微环境。这些发现揭示了FKBP1A在癌症发展和进展中的多方面作用，表明其作为治疗靶点和指导临床药物选择的潜力，并为基于药物的干预措施提供了对患者预后的有价值的见解。
Background and aimFKBP1A, a gene encoding the FK506-binding protein 1A, has emerged as a significant player in cancer progression and prognosis. This study aimed to comprehensively investigate the multifaceted role of FKBP1A in cancer, focusing on its differential expression patterns, prognostic implications, genetic alterations, and associations with the tumor microenvironment.Methods and resultsUsing large-scale datasets, including GTEx, TCGA, HPA, and cBioPortal, we analyzed FKBP1A expression across normal tissues and various cancer types. Our findings revealed that FKBP1A exhibited aberrant upregulation in most human cancers, making it a potential biomarker for malignancy. Moreover, FKBP1A expression correlated with poor overall survival, disease-specific survival, disease-free interval, and progression-free interval in several cancers, indicating its prognostic significance. Genetic alteration analysis showed that FKBP1A gene amplification was prevalent, particularly in ovarian cancer. Furthermore, FKBP1A expression was associated with tumor mutational burden and microsatellite instability, highlighting its potential involvement in tumor-immune response. Notably, FKBP1A expression positively correlated with stromal and immune cell scores, suggesting its role in shaping the tumor microenvironment. Additionally, according to the functional enrichment analysis, experimental validation in lung adenocarcinoma confirmed the role of FKBP1A through the regulation of EGFR signaling by apoptosis, which is consistent with drug sensitivity analysis to some extent.ConclusionIn conclusion, FKBP1A exhibits differential expression in cancer, serves as a prognostic indicator, undergoes genetic alterations, and influences the tumor-immune microenvironment. These findings shed light on the multifaceted role of FKBP1A in cancer development and progression, suggesting its potential as a therapeutic target and guidance of clinical drugs selection, and provide valuable insights into patient prognosis for interventions based on pharmaceuticals.Graphical Abstract