Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis
Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis
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DOI：
10.1073/pnas.97.12.6634
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发表时间：
2000-06-06
影响因子：
11.1
通讯作者：
Eichler, EE
中科院分区：
文献类型：
--
作者：
Bailey, JA;Carrel, L;Eichler, EE
X染色体失活是一种染色体特异性的遗传调控形式，其中一个同源物上的数千个基因在雌性胚胎发生早期变得沉默。尽管X染色体失活的许多方面现在已经被理解，但X染色体失活信号沿着整个染色体长度的传播仍然是个谜。扩展Gartler-Riggs模型[Gartler，S，M，& Riggs，A. D，（1983）Annu，Rev. Genet 17，155-190]，里昂最近提出[里昂，M，F，（1998）Cytogenet Cell Genet，80，133-137]，X染色体上长散布元件（LINE）重复序列的非随机组织可能是其兼性异染色质化的原因。在本文中，我们提供的数据表明，人类X染色体的LINE-1（L1）组成是根本不同于人类常染色体的，X染色体富集2倍的L1重复元件，与最大的富集观察到的一个有限的子集的LINE-1元件是活跃的
X inactivation is a chromosome-specific form of genetic regulation in which thousands of genes on one homologue become silenced early in female embryogenesis, Although many aspects of X inactivation are now understood, the spread of the X inactivation signal along the entire length of the chromosome remains enigmatic. Extending the Gartler-Riggs model [Gartler, S, M, & Riggs, A. D, (1983) Annu, Rev. Genet 17, 155-190], Lyon recently proposed [Lyon, M, F, (1998) Cytogenet Cell Genet, 80, 133-137] that a nonrandom organization of long interspersed element (LINE) repetitive sequences on the X chromosome might be responsible for its facultative heterochromatization. In this paper, we present data indicating that the LINE-1 (L1) composition of the human X chromosome is fundamentally distinct from that of human autosomes, The X chromosome is enriched 2-fold for L1 repetitive elements, with the greatest enrichment observed for a restricted subset of LINE-1 elements that were active