T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses
T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses
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DOI：
10.4049/jimmunol.1103414
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发表时间：
2012-04-01
影响因子：
4.4
通讯作者：
Sospedra, Mireia
中科院分区：
文献类型：
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作者：
Tillack, Kati;Breiden, Petra;Sospedra, Mireia
多形核中性粒细胞构成抵抗感染的第一道防线。在它们消除病原体的策略中，它们释放中性粒细胞胞外陷阱（NETs），即装饰有抗菌蛋白的染色质纤维。net非常有效地捕获和杀死病原体，从而最大限度地减少组织损伤。此外，NETs通过激活浆细胞样树突状细胞来调节炎症反应。在这项研究中，我们发现人类中性粒细胞释放的NETs可以通过降低T细胞的激活阈值直接激活T细胞。nets介导的启动增加了T细胞对特定Ags的反应，甚至对次优刺激的反应，这在静止的T细胞中不会引起反应。NETs介导的T细胞启动需要NETs/细胞接触和TCR信号，但出乎意料的是，我们无法证明TLR9在这一机制中的作用。nets介导的T细胞活化增加了中性粒细胞功能的列表，并证明了先天和适应性免疫反应之间的新联系。免疫学杂志，2012,18(8):3150-3159。
Polymorphonuclear neutrophils constitute the first line of defense against infections. Among their strategies to eliminate pathogens they release neutrophil extracellular traps (NETs), being chromatin fibers decorated with antimicrobial proteins. NETs trap and kill pathogens very efficiently, thereby minimizing tissue damage. Furthermore, NETs modulate inflammatory responses by activating plasmacytoid dendritic cells. In this study, we show that NETs released by human neutrophils can directly prime T cells by reducing their activation threshold. NETs-mediated priming increases T cell responses to specific Ags and even to suboptimal stimuli, which would not induce a response in resting T cells. T cell priming mediated by NETs requires NETs/cell contact and TCR signaling, but unexpectedly we could not demonstrate a role of TLR9 in this mechanism. NETs-mediated T cell activation adds to the list of neutrophil functions and demonstrates a novel link between innate and adaptive immune responses. The Journal of Immunology, 2012, 188: 3150-3159.