Nutritional supplementation affects postoperative oxidative stress and duration of hospitalization in patients with hip fracture
Nutritional supplementation affects postoperative oxidative stress and duration of hospitalization in patients with hip fracture
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DOI：
10.1007/s00508-010-1519-6
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发表时间：
2011-01-01
影响因子：
2.6
通讯作者：
Elmadfa, Ibrahim
中科院分区：
文献类型：
--
作者：
Fabian, Elisabeth;Gerstorfer, Inge;Elmadfa, Ibrahim
目的：本前瞻性随机对照研究的目的是探讨营养补充对老年患者术后氧化应激和住院时间的影响hipfracture.Methods：共14名妇女（=SG）髋部骨折接受了个性化的适应补充剂富含蛋白质和抗氧化剂术后，9作为未补充的对照（=CG）。在术前（T1）、出院当天（T2）和术后3周（T3）采集血样。用自动分析仪测定血浆白蛋白和总蛋白浓度，用分光光度法测定晚期氧化蛋白产物（AOPP）和总抗氧化能力（TAC）。结果：术后对照组血浆白蛋白、TP和TAG均显著下降（T1 > T2，p < 0.01），T2 ~ T3显著升高（p < 0.05），SG无显著变化。这导致了所研究的组之间的TP（T2：SG > CG，p < 0.05）和TAC（T2：SG > CG，p < 0.01）的显著差异。术后两组血浆AOPP和MDA水平均显著升高（T1 < T2，p < 0.01），对照组AOPP和MDA水平维持在显著升高水平（AOPP：T1 <T3，p < 0.05; MDA：T1 < T3，p < 0.01），而SG无显著变化（T2 > T3，p < 0.01）。两组患者术后氧化指标MDA、AOPP均与住院时间呈显著正相关（p < 0.01），TAG、Alb与住院时间呈显著负相关（p < 0.05）。结论：髋部骨折患者术后个体化营养补充可减轻氧化应激，缩短住院时间。
Objective: The objective of this prospective randomized controlled study was to investigate the effect of nutritional supplementation on postoperative oxidative stress and duration of hospitalization in elderly patients with hip fracture.Methods: A total of fourteen women (=SG) with hip fracture received individually adapted supplements enriched with protein and antioxidants postoperatively, nine served as unsupplemented controls (=CG). Blood samples were taken preoperatively (T1), on the day of discharge from hospital (T2) and three weeks thereafter (T3). Plasma concentrations of albumin and total protein (TP) were measured by autoanalysis, advanced oxidation protein products (AOPP) and the total antioxidant capacity (TAC) were determined photometrically. Malondialdehyde (MDA) levels were analyzed by HPLC.Results: Postoperatively, there was a significant (T1 > T2, p < 0.01) decrease in plasma albumin, TP and TAG, followed by a significant (p < 0.05) increase in the period T2-T3 in the CG, but not in the SG. This is resulted in significant differences in TP (T2: SG > CG, p < 0.05) and TAC (T2: SG > CG, p < 0.01) between the investigated groups. Postoperatively, the plasma levels of AOPP and MDA increased significantly (T1 < T2, p < 0.01) in both groups, and remained at the significantly (AOPP: T1 < T3, p < 0.05; MDA: T1 < T3, p < 0.01) elevated level in the CG, but not in the SG (T2 > T3, p < 0.01). Consequently, the oxidant markers MDA and AOPP were significantly positively (p < 0.01), TAG and albumin significantly negatively (p < 0.05) related to duration of hospital stay in both groups.Conclusions: Individualized nutritional supplementation may reduce postoperative oxidative stress and shorten duration of hospitalization in patients with hip fracture.