Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates.
Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates.
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DOI：
10.1248/cpb.c16-00272
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发表时间：
2016-07
影响因子：
1.7
通讯作者：
Keisuke Tomohara;Koji Kasamatsu;T. Yoshimura;T. Furuta;T. Kawabata
中科院分区：
文献类型：
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作者：
Keisuke Tomohara;Koji Kasamatsu;T. Yoshimura;T. Furuta;T. Kawabata
已经开发出短寿命 C-O 轴向手性烯醇化物的对映选择性分子内共轭加成反应。反应以构型反转的方式进行，并以高达 96% 对映体过量 (ee) 的方式提供具有连续四取代和三取代碳中心的二氢苯并呋喃。
Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).