Hedgehog signaling in germ cell migration
Hedgehog signaling in germ cell migration
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DOI：
10.1016/s0092-8674(01)00488-3
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发表时间：
2001-09-21
期刊：
影响因子：
64.5
通讯作者：
Schedl, P
中科院分区：
文献类型：
--
作者：
Deshpande, G;Swanhart, L;Schedl, P
果蝇胚胎的原始性腺由两种细胞类型形成，体细胞性腺前体细胞（SGPs）和生殖细胞，它们起源于遥远的位点。为了到达SGPs，生殖细胞必须经历一系列复杂的细胞运动。虽然有证据表明吸引和排斥信号引导生殖细胞通过胚胎迁移，但这些指导性分子的分子身份仍然难以捉摸。在这里，我们提出的证据表明，刺猬（hh）可能是这样一个有吸引力的指导线索。索马中hh的错误表达诱导生殖细胞迁移到不适当的位置。相反，hh通路的细胞自主成分似乎是生殖细胞迁移所必需的。
The primitive gonad of the Drosophila embryo is formed from two cell types, the somatic gonad precursor cells (SGPs) and the germ cells, which originate at distant sites. To reach the SGPs the germ cells must undergo a complex series of cell movements. While there is evidence that attractive and repulsive signals guide germ cell migration through the embryo, the molecular identity of these instructive molecules has remained elusive. Here, we present evidence suggesting that hedgehog (hh) may serve as such an attractive guidance cue. Misexpression of hh in the soma induces germ cells to migrate to inappropriate locations. Conversely, cell-autonomous components of the hh pathway appear to be required in the germline for proper germ cell migration.