SEROLOGIC REACTIONS TO SKIN HOMOGRAFTS OF VARIOUS SIZES IN RAT
SEROLOGIC REACTIONS TO SKIN HOMOGRAFTS OF VARIOUS SIZES IN RAT
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DOI：
10.1111/j.1749-6632.1964.tb34700.x
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发表时间：
1964-01-01
期刊：
影响因子：
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通讯作者：
STETSON, CA
中科院分区：
文献类型：
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作者：
BALLANTY.DL;STETSON, CA
两个近交系大鼠对同种异体皮肤移植物的体液抗体反应在时间和程度上有很大差异。Lewis受体在移植后第6天出现细胞毒抗体，但滴度一直不高，到第26天下降到较低水平。另一方面，BN接受者在第六天没有表现出循环抗体，但随后出现了显著更高的抗体水平，并在整个26天的观察期内继续上升。在广泛的范围内，皮肤移植物的大小与所获得的抗体效价几乎没有关系，尽管血清学证据表明有积极的免疫反应，但大量的同种皮肤移植物显示出矛盾的延长存活时间。这些数据与以下假设一致，即血清细胞毒抗体以外的某些特定因素是导致大量同种异体移植物长期存活的限制因素。
The humoral antibody responses to reciprocal skin homografts between two inbred strains of rat differed considerably in timing and in degree. The Lewis recipients developed cytotoxic antibody by the sixth day after grafting, but the titers achieved were never high and declined to low levels by the 26th day. BN recipients, on the other hand, did not show circulating antibodies on the sixth day, but then developed substantially higher antibody levels which continued to rise throughout the 26-day observation period. Over a wide range, the size of the skin graft bore little relation to the titer of antibody achieved, Massive skin homografts exhibited paradoxically prolonged survival, in spite of serological evidence of an active immune response. The data are consistent with the hypothesis that some specific factor other than the cytotoxic antibody of serum is the limiting factor responsible for the long survival of massive homografts.