Soystatin (VAWWMY), a Novel Bile Acid-Binding Peptide, Decreased Micellar Solubility and Inhibited Cholesterol Absorption in Rats
Soystatin (VAWWMY), a Novel Bile Acid-Binding Peptide, Decreased Micellar Solubility and Inhibited Cholesterol Absorption in Rats
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DOI：
10.1271/bbb.100338
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发表时间：
2010-08-01
影响因子：
1.6
通讯作者：
Kanamaru, Yoshihiro
中科院分区：
文献类型：
--
作者：
Nagaoka, Satoshi;Nakamura, Atsushi;Kanamaru, Yoshihiro
本研究旨在鉴定一种源自大豆蛋白的新型肽，该肽可诱导抑制体内胆固醇吸收。 VAWWMY（Val-Ala-Trp-Trp-Met-Tyr，指定为大豆抑素）比大豆蛋白消化水解产物 (SPH) 或酪蛋白胰蛋白酶水解产物 (CTH) 具有显着更强的结合胆汁酸的能力。令人惊讶的是，VAWWMY 的胆汁酸结合能力几乎与降胆固醇药物考来烯胺一样强。 VAWWMY 存在下胆固醇的胶束溶解度显着低于 SPH 或 CTH 存在下的胆固醇胶束溶解度。我们发现源自大豆甘氨酸的大豆抑素可作为体内胆固醇吸收的抑制剂。
This study was designed to identify a novel peptide derived from soybean protein that induces inhibition of cholesterol absorption in vivo. VAWWMY (Val-Ala-Trp-Trp-Met-Tyr, designated soystatin) had a significantly greater ability to bind bile acid than soybean protein peptic hydrolysate (SPH) or casein tryptic hydrolysate (CTH). Surprisingly, the bile-acid binding ability of VAWWMY was almost as strong as that of the hypocholesterolemic medicine cholestyramine. The micellar solubility of cholesterol was significantly lower in the presence of VAWWMY than in that of SPH or CTH. We found that soystatin derived from soybean glycinin acted as an inhibitor of cholesterol absorption in vivo.