Macrophage cytotoxicity in the mouse immune response against a skin allograft.
Macrophage cytotoxicity in the mouse immune response against a skin allograft.
复制标题
小鼠针对同种异体皮肤移植物的免疫反应中的巨噬细胞细胞毒性。
DOI：
10.4049/jimmunol.114.1_part_1.195
复制
发表时间：
1975
影响因子：
4.4
通讯作者：
J. Hamburger
中科院分区：
文献类型：
--
作者：
A. Dimitriu;M. Dy;N. Thomson;J. Hamburger
Macrophage-rich peritoneal cell populations from C57BL/6 mice grafted with DBA/2 skin were found to be cytotoxic against 51Cr-labeled target cells from the donor strain. Normal peritoneal macrophages were also rendered cytotoxic by incubation with acellular supernatants of mixed lymphocyte cultures (MLC) between an allograft recipient and a donor mouse. Supernatants alone were not cytotoxic. The macrophage arming factor(s) was found in supernatants when the MLC was performed after more than 6 to 9 days following grafting. In order to produce MAF, sensitized lymphocytes must usually be stimulated in a specific way by donor type cells. The armed macrophage cytotoxicity was, however, not found to be specific in these experiments.
