Cardiac function during rest and exercise in patients with mitral valve prolapse. Role of radionuclear angiocardiography.
Cardiac function during rest and exercise in patients with mitral valve prolapse. Role of radionuclear angiocardiography.
复制标题
二尖瓣脱垂患者休息和运动时的心功能。
DOI：
10.1016/0002-9149(81)90283-6
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Jones,RH
中科院分区：
文献类型：
--
作者：
Newman,GE;Gibbons,RJ;Jones,RH
二尖瓣脱垂综合征和缺血性冠状动脉疾病的临床特征重叠，使得这两种疾病难以区分。许多患者同时患有这两种疾病。本研究评估了单纯二尖瓣脱垂患者和二尖瓣脱垂伴冠状动脉疾病患者在休息和运动时心室功能的变化。12例经血管造影证实二尖瓣脱垂且冠状动脉解剖结构正常的患者和11例冠状动脉解剖结构正常且无二尖瓣脱垂的患者在运动过程中射血分数增加且无室壁运动异常。另外11例超声心动图显示二尖瓣脱垂患者在运动过程中心室功能的变化与血管造影显示二尖瓣脱垂和冠状动脉解剖正常的患者相似。与此相反，11例二尖瓣脱垂和冠状动脉狭窄的患者中有6例在血管造影中表现出射血分数降低，并在运动期间表现出室壁运动异常。这些结果表明，单独的二尖瓣脱垂在休息和运动时对心室功能没有不利影响，运动引起的心室功能异常与冠状动脉疾病的存在和严重程度有关，而与二尖瓣脱垂无关。
The clinical features of mitral valve prolapse syndrome and ischemic coronary disease overlap, making differentiation of the two conditions difficult. Furthermore, many patients have both conditions. This study assessed changes in ventricular function during rest and exercise in patients with mitral valve prolapse alone and in patients with prolapse and concomitant coronary artery disease. Twelve patients with angiographically documented mitral valve prolapse and normal coronary anatomy and 11 patients with normal coronary anatomy and no mitral valve prolapse had increased ejection fraction and demonstrated no wall motion abnormality during exercise. Changes in ventricular function during exercise in 11 additional patients with mitral valve prolapse demonstrated on echocardiography were similar to those in the group with mitral valve prolapse and normal coronary anatomy seen on angiography. In contrast, 6 of 11 patients with mitral valve prolapse and coronary arterial stenosis demonstrated on angiography had a decreased ejection fraction and exhibited wall motion abnormalities during exercise. These results suggest that mitral valve prolapse alone has no detrimental effect on ventricular function during rest and exercise and that exercise-induced abnormalities in ventricular function are related to the presence and severity of coronary artery disease and not to mitral valve prolapse.