Phylogeny of the genus Flavivirus
Phylogeny of the genus Flavivirus
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DOI：
10.1128/jvi.72.1.73-83.1998
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发表时间：
1998-01-01
影响因子：
5.4
通讯作者：
Cropp, CB
中科院分区：
文献类型：
--
作者：
Kuno, G;Chang, GJJ;Cropp, CB
我们进行了全面的系统发育研究，以建立黄病毒属病毒之间的遗传关系，并比较基于分子系统发育的分类，与现有的血清学方法。通过使用定量定义的组合（自助支持水平和成对核苷酸序列同一性），可以将病毒分类为簇、进化枝和种。我们的系统发育研究首次揭示，从推定的祖先进化出两个分支，即非媒介病毒簇和媒介病毒簇，并且从后者簇中出现了蜱传病毒簇和蚊传病毒簇。假设节肢动物协会是一种获得性性状的理论是正确的，这三个簇之间的成对核苷酸序列同一性提供了支持数据，表明非载体簇首先进化，然后依次分离蜱传和蚊传病毒簇。在我们的研究中建立的分支与现有的抗原复合物显着相关。我们还解决了许多过去的分类学问题，通过建立抗原性未分类的病毒的系统发育关系，与完善的病毒和确定同义病毒。
We undertook a comprehensive phylogenetic study to establish the genetic relationship among the viruses of the genus Flavivirus and to compare the classification based on molecular phylogeny,vith the existing serologic method. By using a combination of quantitative definitions (bootstrap support level and the pairwise nucleotide sequence identity), the viruses could be classified into clusters, clades, and species. Our phylogenetic study revealed for the first time that from the putative ancestor two branches, non-vector and vector-borne virus clusters, evolved and from the latter cluster emerged tick-borne and mosquito-borne virus clusters. Provided that the theory of arthropod association being an acquired trait was correct, pairwise nucleotide sequence identity among these three clusters provided supporting data for a possibility that the non-vector cluster evolved first, followed by the separation of tick-borne and mosquito-borne virus clusters in that order. Clades established in our study correlated significantly with existing antigenic complexes. We also resolved many of the past taxonomic problems by establishing phylogenetic relationships of the antigenically unclassified viruses,vith the well-established viruses and by identifying synonymous viruses.