Diffusion tensor Imaging predicts hyperacute spinal cord injury severity
Diffusion tensor Imaging predicts hyperacute spinal cord injury severity
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DOI：
10.1089/neu.2006.0253
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发表时间：
2007-06-01
影响因子：
4.2
通讯作者：
Song, Sheng-Kwei
中科院分区：
文献类型：
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作者：
Loy, David N.;Kim, Joong Hee;Song, Sheng-Kwei
在超急性期关注腹侧白质（VWM）保存的实验策略对于我们更好地理解创伤性脊髓损伤（SCI）后的功能恢复具有很大的潜力。由于缺乏亚临床病理生理变化和脊髓白质损伤的体内测量，人类脊髓损伤与来自啮齿动物模型的快速积累数据的关键比较受到限制。常规MR序列显示的脊髓水肿和实质内出血在预测脊髓损伤动物模型和人类患者的功能结局方面价值有限。我们最近证明，体内衍生扩散张量成像（DTI）参数是脊髓白质损伤的敏感和特异性生物标志物。在本研究中，采用无创活体DTI评估C57BL/6小鼠在轻度（0.3 mm）、中度（0.6 mm）或重度（0.9 mm）挫伤后3小时的白质。在超急性期，相对各向异性图在所有程度的损伤中提供了良好的灰质-白质对比。体内dti衍生的轴向扩散测量可区分轻度、中度和重度挫伤性脊髓损伤，具有良好的组织学相关性。背柱和VWM之间白质损伤严重程度的横截面区域测量随脊髓位移的增加而变化，其模式与脊髓粘弹性特性一致。
Experimental strategies that focus on ventral white matter (VWM) preservation during the hyperacute phase hold great potential for our improved understanding of functional recovery following traumatic spinal cord injury (SCI). Critical comparisons of human SCI to rapidly accumulating data derived from rodent models are limited by a basic lack of in vivo measures of subclinical pathophysiologic changes and white matter damage in the spinal cord. Spinal cord edema and intra-parenchymal hemorrhage demonstrated with routine MR sequences have limited value for predicting functional outcomes in SCI animal models and in human patients. We recently demonstrated that in vivo derived diffusion tensor imaging (DTI) parameters are sensitive and specific biomarkers for spinal cord white matter damage. In this study, non-invasive in vivo DTI was utilized to evaluate the white matter of C57BL/6 mice 3 h after mild (0.3 mm), moderate (0.6 mm), or severe (0.9 mm) contusive SCI. In the hyperacute phase, relative anisotropy maps provided excellent gray-white matter contrast in all degrees of injury. In vivo DTI-derived measurements of axial diffusion differentiated between mild, moderate, and severe contusive SCI with good histological correlation. Cross-sectional regional measurements of white matter injury severity between dorsal columns and VWM varied with increasing cord displacement in a pattern consistent with spinal cord viscoelastic properties.