Genetic properties influencing the evolvability of gene expression
Genetic properties influencing the evolvability of gene expression
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DOI：
10.1126/science.1140247
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发表时间：
2007-07-06
期刊：
影响因子：
56.9
通讯作者：
Hartl, Daniel L.
中科院分区：
文献类型：
--
作者：
Landry, Christian R.;Lemos, Bernardo;Hartl, Daniel L.
确定影响其进化的基因网络的特性是一个基本的研究目标。然而，进化模式不能仅仅从自然变异的分布中推断出来，因为选择与人口统计学和突变率相互作用，形成多态性和分化。我们估计了自然发生的突变对基因表达的影响，同时最小化了自然选择的影响。我们证明基因表达对突变的敏感性随着突变靶大小的增加和TATA盒子的存在而增加。对突变更敏感的基因对系统环境扰动和随机噪声也更敏感。这些结果为基因表达的可进化性提供了一个机制基础，可以作为调控进化的现实模型的基础。
Identifying the properties of gene networks that influence their evolution is a fundamental research goal. However, modes of evolution cannot be inferred solely from the distribution of natural variation, because selection interacts with demography and mutation rates to shape polymorphism and divergence. We estimated the effects of naturally occurring mutations on gene expression while minimizing the effect of natural selection. We demonstrate that sensitivity of gene expression to mutations increases with both increasing trans-mutational target size and the presence of a TATA box. Genes with greater sensitivity to mutations are also more sensitive to systematic environmental perturbations and stochastic noise. These results provide a mechanistic basis for gene expression evolvability that can serve as a foundation for realistic models of regulatory evolution.