Expression of Bcl-2 in olfactory neuroblastoma and its association with chemotherapy and survival
Expression of Bcl-2 in olfactory neuroblastoma and its association with chemotherapy and survival
复制标题
DOI：
10.1016/j.otohns.2008.03.011
复制
发表时间：
2008-11-01
影响因子：
3.4
通讯作者：
Chung, Jin-Haeng
中科院分区：
文献类型：
--
作者：
Kim, Jeong-Whun;Kong, Il Gyu;Chung, Jin-Haeng
OBJECTIVE: This study aimed to identify the prognostic value of tumor markers in olfactory neuroblastoma (ONB).STUDY DESIGN AND SETTING: Seventeen patients with ONB (23 tumor specimens) were included. Each specimen was studied for bcl-2, p53, MIC-2 by immunohistochemistry and for N-myc by chromogenic in situ hybridization.RESULTS: Twelve (70%) of 17 patients and 15 (65%) of 23 specimens showed positive reactivity for bcl-2. Of seven patients who were treated with neoadjuvant chemotherapy, one patient with diffuse bcl-2 expression achieved complete remission. Another patient without bcl-2 expression had no response to chemotherapy. Five patients who showed partial positivity achieved partial remission. Survival and bcl-2 expression tended to correlate, but it was not statistically significant (P = 0.06). All of the ONB specimens were negative for N-myc. Positive immunoreactivity for MIC-2 or p53 was found only in one specimen.CONCLUSION: Bcl-2 expression was commonly found in ONB and the immunoreactivity for bcl-2 might predict response to neoadjuvant chemotherapy. In addition. Bcl-2 expression tended to be associated with worse survival. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
