Tissue factor, protease activated receptors and pathologic heart remodelling.
Tissue factor, protease activated receptors and pathologic heart remodelling.
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DOI：
10.1160/th14-03-0243
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发表时间：
2014-11
影响因子：
6.7
通讯作者：
Pawlinski R
中科院分区：
文献类型：
--
作者：
Antoniak S;Sparkenbaugh E;Pawlinski R
组织因子是凝血级联反应的主要启动者，在止血和血栓形成中起重要作用。此外，组织因子和凝血蛋白酶通过蛋白酶激活受体的激活促进许多细胞应答。心脏是表现出高水平的组成性组织因子表达的器官。本文综述了组织因子、凝血蛋白酶和蛋白酶激活受体在心脏止血中的作用以及与心肌梗死、病毒性心肌炎和高血压相关的病理性心脏重构。
Tissue factor is the primary initiator of coagulation cascade and plays an essential role in hemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to the many cellular responses via activation of protease activated receptors. Heart is the organ demonstrating high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart hemostasis and the pathological heart remodeling associated with myocardial infarction, viral myocarditis and hypertension.