Sphingomyelin in the suppression of colon tumors: prevention versus intervention
Sphingomyelin in the suppression of colon tumors: prevention versus intervention
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DOI：
10.1016/j.abb.2003.08.023
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发表时间：
2003-11-15
影响因子：
3.9
通讯作者：
Schmelz, EM
中科院分区：
文献类型：
--
作者：
Lemonnier, LA;Dillehay, DL;Schmelz, EM
在日粮中复杂鞘脂水解后，肠细胞经常暴露于鞘脂代谢产物，即神经酰胺和鞘碱。这些代谢物是已知的细胞生长、分化和死亡的调节因子。饮食中的非药理学量已被证明可以抑制小鼠早期化学诱导的结肠癌。为了区分鞘磷脂补充剂的化学预防和化学治疗作用，在小鼠肿瘤发生前后分别饲喂鞘磷脂。两种应用都能显著减少肿瘤形成，组间无显著差异，表明鞘脂在肿瘤化学预防方面与早期干预一样有效。在膳食鞘磷脂抑制肿瘤形成的过程中，细胞增殖和凋亡率的正常化，而不是诱导分化的正常化，似乎是关键的参与者。这可能对利用鞘脂替代传统药物的癌症预防或治疗策略的发展产生影响。(C) 2003 Elsevier Inc.版权所有。
Intestinal cells are regularly exposed to sphingolipid metabolites, i.e., ceramide and sphingoid bases, after hydrolysis of complex sphingolipids from the diet. These metabolites are known regulators of cell growth, differentiation, and death. Non-pharmacological amounts in the diet have been shown to inhibit early stages of chemically induced colon cancer in mice. To distinguish between chemopreventive and chemotherapeutic effects of sphingomyelin supplements, mice were fed sphingomyelin before and after tumor initiation. Both applications drastically reduced tumor formation, without a significant difference among the groups, indicating that sphingolipids are as effective in the chemoprevention of tumors as in early intervention. The normalization of cell proliferation and rate of apoptosis, but not the induction of differentiation, seem to be key players in the suppression of tumor formation by dietary sphingomyelin. This may have implications for the development of a cancer prevention or treatment strategy with sphingolipids as an alternative to conventional drugs. (C) 2003 Elsevier Inc. All rights reserved.