Meta-analytic clustering of the insular cortex: characterizing the meta-analytic connectivity of the insula when involved in active tasks.
Meta-analytic clustering of the insular cortex: characterizing the meta-analytic connectivity of the insula when involved in active tasks.
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DOI：
10.1016/j.neuroimage.2012.04.012
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发表时间：
2012-08-01
期刊：
影响因子：
5.7
通讯作者：
Vercelli A
中科院分区：
文献类型：
--
作者：
Cauda F;Costa T;Torta DM;Sacco K;D'Agata F;Duca S;Geminiani G;Fox PT;Vercelli A
人类大脑皮层已经被包裹的基础上休息状态的功能连接和扩散张量成像。当参与主动任务时，对大脑皮层的组织结构知之甚少。我们探讨了这个问题，使用一种新的荟萃分析聚类方法。我们查询了BrainMap数据库，要求涉及正常受试者的记录岛叶皮层激活的论文，检索到1305篇论文，涉及22，872名受试者，共2957个病灶。用几种不同的方法分析数据，其中一些方法是专门为这项工作设计的。我们使用从BrainMap数据库获得的数据的元分析连接建模和元分析聚类。我们进行了聚类分析，细分具有均匀连接性的区域，并使用Voronoi细分对激活灶进行密度分析。我们的研究结果证实并扩展了以前的研究结果，获得了静息状态连接的前，后和左，右岛。他们表明，第一次，一些块的前额叶前部和后部岛之间发挥枢纽的作用，证实了他们的激活在几个不同的范例。这一发现支持了前额叶所属的神经网络与显著性检测有关的观点。两侧的岛可以分成两个集群，前部和后部：前部的特点是与额叶，扣带回，顶叶，小脑和前岛高度连接的区域的连接的注意模式，而后部的特点是与感觉运动，颞叶和后扣带回区域的连接更局部的连接模式。在右侧更好地表征的这种前后细分，使用基于连接的聚类比使用基于行为的聚类的结果更尖锐。属于前额叶的回路是非常均匀的，并且它们的块在基于MACM的配置文件的多维标度中处于中心位置，而属于后额叶的回路，特别是在左侧，位于外围和稀疏，从而表明后额叶的回路具有更异质的连接性。前簇主要由认知激活，而后簇主要由内感受、知觉和情绪激活。
The human insula has been parcellated on the basis of resting state functional connectivity and diffusion tensor imaging. Little is known about the organization of the insula when involved in active tasks. We explored this issue using a novel meta-analytic clustering approach. We queried the BrainMap database asking for papers involving normal subjects that recorded activations in the insular cortex, retrieving 1305 papers, involving 22,872 subjects and a total of 2957 foci. Data were analyzed with several different methodologies, some of which expressly designed for this work. We used meta-analytic connectivity modeling and meta-analytic clustering of data obtained from the BrainMap database. We performed cluster analysis to subdivide the insula in areas with homogeneous connectivity, and density analysis of the activated foci using Voronoi tessellation. Our results confirm and extend previous findings obtained investigating the resting state connectivity of the anterior–posterior and left–right insulae. They indicate, for the first time, that some blocks of the anterior insula play the role of hubs between the anterior and the posterior insulae, as confirmed by their activation in several different paradigms. This finding supports the view that the network to which the anterior insula belongs is related to saliency detection. The insulae of both sides can be parcellated in two clusters, the anterior and the posterior: the anterior is characterized by an attentional pattern of connectivity with frontal, cingulate, parietal, cerebellar and anterior insular highly connected areas, whereas the posterior is characterized by a more local connectivity pattern with connections to sensorimotor, temporal and posterior cingulate areas. This antero–posterior subdivision, better characterized on the right side, results sharper with the connectivity based clusterization than with the behavioral based clusterization. The circuits belonging to the anterior insula are very homogeneous and their blocks in multidimensional scaling of MACM-based profiles are in central position, whereas those belonging to the posterior insula, especially on the left, are located at the periphery and sparse, thus suggesting that the posterior circuits bear a more heterogeneous connectivity. The anterior cluster is mostly activated by cognition, whereas the posterior is mostly activated by interoception, perception and emotion.