The development of somatosensory neurons: Insights into pain and itch.

The development of somatosensory neurons: Insights into pain and itch.
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DOI:
10.1016/bs.ctdb.2020.10.005
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发表时间:
2021
影响因子:
--
通讯作者:
Luo W
Luo W
中科院分区:
生物学2区
文献类型:
--
作者:
Cranfill SL;Luo W

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Primary nociceptors are a heterogeneous class of peripheral somatosensory neurons, responsible for detecting noxious, pruriceptive, and thermal stimuli. These neurons are further divided into several molecularly defined subtypes that correlate well with their functional sensory modalities and morphological features. During development, all nociceptors arise from a common pool of embryonic precursors, then segregate progressively into their mature specialized phenotypes. In this review, we summarize the intrinsic transcriptional programs and extrinsic trophic factor signaling mechanisms that interact to control nociceptor diversification. We also discuss how recent transcriptome profiling studies have significantly advanced the field of sensory neuron development.
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