Spatiotemporal ontogeny of brain wiring
Spatiotemporal ontogeny of brain wiring
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DOI：
10.1126/sciadv.aav9694
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发表时间：
2019-06-01
期刊：
影响因子：
13.6
通讯作者：
Hilgetag, C. C.
中科院分区：
文献类型：
--
作者：
Goulas, A.;Betzel, R. F.;Hilgetag, C. C.
脊椎动物和无脊椎动物大脑的神经网络为认知和行为提供了解剖学骨架。大脑各区域之间的连接具有异质性强度的特点，这可以用线路成本和同质性原理来简洁地描述。此外，大脑表现出一种独特的全球网络拓扑结构，包括模块和集线器。然而，导致观察到的大脑区域间布线原理和网络拓扑结构的机制尚不清楚。本研究借助计算模型，证明了一种基于异时性和空间有序神经发育梯度的机制，在没有活动依赖的可塑性或轴突引导线索的情况下，可以重建包括苍蝇和人类在内的多种成人脑连接体的大部分布线原理（平均83%）和整体网络拓扑结构（平均80%）。总而言之，空间和时间是一个简约的、合理的大脑神经发育机制的关键组成部分，具有潜在的普遍范围，包括脊椎动物和无脊椎动物的大脑。
The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global network topology, including modules and hubs. However, the mechanisms resulting in the observed interregional wiring principles and network topology of brains are unknown. Here, with the aid of computational modeling, we demonstrate that a mechanism based on heterochronous and spatially ordered neurodevelopmental gradients, without the involvement of activity-dependent plasticity or axonal guidance cues, can reconstruct a large part of the wiring principles (on average, 83%) and global network topology (on average, 80%) of diverse adult brain connectomes, including fly and human connectomes. In sum, space and time are key components of a parsimonious, plausible neurodevelopmental mechanism of brain wiring with a potential universal scope, encompassing vertebrate and invertebrate brains.