Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host.
Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host.
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DOI：
10.3389/fcimb.2023.1274175
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
在过去的几十年里，结核病的病原体结核分枝杆菌(M.tb)的耐药性(DR)菌株日益流行，并对全球公共健康构成威胁。这些菌株从多重耐药(MDR)到广泛耐药(XDR)不等，使它们非常难以治疗。此外，2019年冠状病毒病(新冠肺炎)大流行目前和未来对耐药结核病发展的影响仍不清楚。虽然已经进行了详尽的研究来描述结核分枝杆菌细胞膜的独特性，但人们对其组成如何变化与耐药性获得的关系知之甚少。这一知识对于了解耐药结核分枝杆菌菌株抵抗抗结核药物的能力至关重要，并为我们提供了未来抗击这些难以治疗的菌株的抗结核药物设计的信息。在这篇综述中，我们讨论了结核分枝杆菌细胞膜的复杂性，以及最近对结核分枝杆菌结构和生化变化与耐药性的关系的研究。此外，我们将描述目前已知的结核分枝杆菌耐药性对感染结局的影响，重点是它对健康、宿生菌和亚临床结核病的影响。
In the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a threat to worldwide public health. These strains range from multi (MDR) to extensively (XDR) drug-resistant, making them very difficult to treat. Further, the current and future impact of the Coronavirus Disease 2019 (COVID-19) pandemic on the development of DR-TB is still unknown. Although exhaustive studies have been conducted depicting the uniqueness of the M.tb cell envelope, little is known about how its composition changes in relation to drug resistance acquisition. This knowledge is critical to understanding the capacity of DR-M.tb strains to resist anti-TB drugs, and to inform us on the future design of anti-TB drugs to combat these difficult-to-treat strains. In this review, we discuss the complexities of the M.tb cell envelope along with recent studies investigating how M.tb structurally and biochemically changes in relation to drug resistance. Further, we will describe what is currently known about the influence of M.tb drug resistance on infection outcomes, focusing on its impact on fitness, persister-bacteria, and subclinical TB.
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影响因子：
5.2
作者：
Allué-Guardia A;García JI;Torrelles JB
通讯作者：
Torrelles JB
影响因子：
5.8
作者：
Bailo, Rebeca;Bhatt, Apoorva;Ainsa, Jose A.
通讯作者：
Ainsa, Jose A.
影响因子：
2.8
作者：
Amin, Anita G.;Goude, Renan;Parish, Tanya
通讯作者：
Parish, Tanya
DOI：
10.1073/pnas.1209126109
发表时间：
2012-11-13
影响因子：
11.1
作者：
Brown, Stephanie;Xia, Guoqing;Walker, Suzanne
通讯作者：
Walker, Suzanne
影响因子：
3.9
作者：
Besra, GS;Brennan, PJ
通讯作者：
Brennan, PJ