Resolution of serous macular detachment after intravitreal triamcinolone acetonide treatment of patients with branch retinal vein occlusion
Resolution of serous macular detachment after intravitreal triamcinolone acetonide treatment of patients with branch retinal vein occlusion
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DOI：
10.1097/00006982-200510000-00007
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发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Karacorlu, SA
中科院分区：
文献类型：
--
作者：
Karacorlu, M;Ozdemir, H;Karacorlu, SA
目的：目的探讨玻璃体腔注射曲安奈德治疗视网膜分支静脉阻塞（branch retinal vein occlusion，BRVO）浆液性黄斑脱离的疗效。本研究的合格标准包括临床和血管造影可检测的黄斑囊样水肿（CME），其中通过光学相干断层扫描（OCT）记录了浆液性黄斑脱离的存在。玻璃体腔注射曲安奈德0.1mL（4mg）后，观察其视觉和解剖学反应。结果：所有患眼注射曲安奈德后，CME和浆液性黄斑脱离消退。术后3个月复发1眼（12.5%），术后6个月复发2眼（25%）。复发的患者重新接受治疗。术后1个月无视力丧失，所有患眼视力均有所改善。在3个月时，没有眼睛从基线丧失视力，7只眼睛（87.5%）显示出改善。在6个月，再次没有眼睛失去了从基线的视力，7眼（87.5%）保持改善visual acuity.Conclusions：我们的研究的初步结果显示，及时解决浆液性黄斑脱离与相应的改善视力的患者CME继发于BRVO。需要更长时间的随访和更大规模的研究来评估长期疗效和安全性。
Purpose: To evaluate the effect of intravitreal triamcinolone acetonide on serous macular detachment in patients with branch retinal vein occlusion (BRVO).Methods: Eight eyes of 8 patients with BRVO (6 men and 2 women; age range, 52-76 years) made up the study population. The eligibility criteria for this study included clinically and angiographically detectable cystoid macular edema (CME) in which the presence of serous macular detachment was documented by optical coherence tomography (OCT). After intravitreal injection of 0.1 mL (4 mg) of triamcinolone acetonide, the visual and anatomical responses were observed.Results: In all eyes, after injection of triamcinolone acetonide, CME and serous macular detachment regressed. At 3 and 6 months, CME and serous macular detachment had recurred in 1 eye (12.5%) and 2 eyes (25%), respectively. Patients with recurrence were retreated. No eyes lost vision at 1 month, and all eyes showed improvement. At 3 months, no eyes had lost vision from baseline, and 7 eyes (87.5%) showed improvement. At 6 months, again no eyes had lost vision from baseline, and 7 eyes (87.5%) maintained improved visual acuity.Conclusions: The preliminary results of our study showed prompt resolution of serous macular detachment with corresponding improved visual acuity in patients with CME secondary to BRVO. Further study with longer follow-up and a larger series is warranted to assess the long-term efficacy and safety.