Data collection as a barrier to personalized medicine.
Data collection as a barrier to personalized medicine.
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DOI：
10.1016/j.tips.2014.11.002
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发表时间：
2015-02
影响因子：
13.8
通讯作者：
D. Zakim;M. Schwab
中科院分区：
文献类型：
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作者：
D. Zakim;M. Schwab
基础生命科学研究为个性化医疗提供了希望。然而，从实验室到床边的翻译步骤并不简单。临床研究的结果很难复制，部分原因是研究队列的表型定义不明确。在这里，我们讨论了计算机技术如何改善临床数据的收集，以使从基础科学的见解转化为有效的临床指南。
Basic life science research holds the promise of personalizing medical care. However, translation steps from the laboratory to the bedside are not trivial. Results from clinical research are difficult to replicate in part because study cohorts are poorly defined phenotypically. Here, we discuss how computer technology can improve the collection of clinical data to enable translation of insights from basic science to validated clinical guidelines.