Non-invasive markers of ureteropelvic junction obstruction
Non-invasive markers of ureteropelvic junction obstruction
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DOI：
10.1007/s00345-007-0201-8
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发表时间：
2007-10-01
影响因子：
3.4
通讯作者：
Schanstra, Joost P.
中科院分区：
文献类型：
--
作者：
Decramer, Stephane;Bascands, Jean-Loup;Schanstra, Joost P.
疾病临床进展的非侵入性预后是高度关注的，特别是在新生儿和儿童中。新生儿肾盂输尿管连接部梗阻需要密切和有创的监测，以确定肾盂成形术的必要性。许多研究小组已经开始研究，目的是找到UPJ梗阻的非侵入性生物标志物。采取了两种不同的战略。一种策略是基于在UPJ梗阻动物模型中获得的知识，已经确定了许多严重UPJ梗阻的个体尿标记物。结合这些标志物可以预测哪些患者需要手术，哪些患者UPJ梗阻将自发解决。另一种策略是基于尿蛋白质组学。在这种策略中，整个尿蛋白质组被探测与UPJ阻塞程度相关的一组生物标志物。在随后的步骤中，这些尿生物标志物组用于预测UPJ梗阻患者的临床进展。这种基于蛋白质组学的策略可以提前几个月预测UPJ梗阻新生儿的临床进展。这两种策略将是互补的，并有望在不久的将来取代UPJ梗阻新生儿的侵入性随访。
Non-invasive prognosis of the clinical progression of disease is of high interest, especially in newborn and children. Neonatal ureteropelvic (UPJ) junction obstruction needs close and invasive surveillance to determine the necessity of pyeloplasty. A number of groups have initiated research with the aim to find non-invasive biomarkers for UPJ obstruction. Two different strategies have been followed. One strategy, based on the knowledge obtained in animal models of UPJ obstruction, has identified a number of individual urinary markers of severe UPJ obstruction. Combining these markers might allow prediction of which patients will require surgery and in which patients UPJ obstruction will spontaneously resolve. The other strategy is based on urinary proteomics. In this strategy the entire urinary proteome is probed for a set of biomarkers that correlates with the degree of UPJ obstruction. In subsequent steps, these sets of urinary biomarkers are used for prediction of the clinical evolution of UPJ obstruction patients. This proteomic-based strategy allowed prediction, several months in advance, of the clinical evolution of neonates with UPJ-obstruction. Both strategies will be complementary and will hopefully replace in the near future the invasive follow-up of newborns with UPJ obstruction.