MATERNAL PREVALENCE OF TOXOPLASMA ANTIBODY BASED ON ANONYMOUS NEONATAL SEROSURVEY - A GEOGRAPHICAL ANALYSIS
MATERNAL PREVALENCE OF TOXOPLASMA ANTIBODY BASED ON ANONYMOUS NEONATAL SEROSURVEY - A GEOGRAPHICAL ANALYSIS
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DOI：
10.1017/s0950268800050755
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发表时间：
1993-02-01
影响因子：
4.2
通讯作者：
PECKHAM, CS
中科院分区：
文献类型：
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作者：
ADES, AE;PARKER, S;PECKHAM, CS
共有12902新生儿样本收集在吸水纸上进行常规代谢筛查匿名检测弓形虫抗体。血清阳性率从伦敦市中心的19.5%到伦敦郊区的11.6%和非大都市区的7.6%不等。这种变化似乎与每个地区的活产比例与英国以外出生的妇女有关。然而，额外的地理差异仍然存在，在英国出生的妇女的血清阳性率估计为12.7%，在内伦敦。伦敦郊区为7.5%，非大都市地区为5.5%。这些估计值大大低于英国以前报告的产前血清。广泛的地理差异突出表明需要进一步研究，以确定不同传播途径的相对重要性。
A total of 12902 neonatal samples collected on absorbent paper for routine metabolic screening were tested anonymously for antibodies to toxoplasma. Seroprevalence varied from 19.5% in inner London, to 11.6% in suburban London, and 7.6% in non-metropolitan districts. Much of this variation appeared to be associated with the proportions of livebirths in each district to women born outside the UK. However, additional geographical variation remained and seroprevalence in UK-born women was estimated to be 12.7% in inner London. 7.5% in suburban London, and 5.5% in non-metropolitan areas. These estimates are considerably lower than any previously reported in antenatal sera in the UK. The wide geographical variation highlights a need for further research to determine the relative importance of different routes of transmission.