Increased expression of L-type high voltage-gated calcium channel α1 and α2/δ subunits in mouse brain after chronic nicotine administration
Increased expression of L-type high voltage-gated calcium channel α1 and α2/δ subunits in mouse brain after chronic nicotine administration
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DOI：
10.1016/j.molbrainres.2004.11.002
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发表时间：
2005-04-27
期刊：
影响因子：
--
通讯作者：
Ohkuma, S
中科院分区：
文献类型：
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作者：
Hayashida, S;Katsura, M;Ohkuma, S
我们研究了慢性尼古丁给药对小鼠大脑皮层高压门控钙通道（HVCCs）的影响。治疗显著增加了α 1C、α 1D、α 1F和α 2/ α 1亚基的表达，而β 4亚基无变化。[H-3]地尔硫卓与颗粒组分的结合随着Bmax值的增加而增加。这些结果表明，慢性尼古丁治疗可上调l型hvcc，这是由于α 1和α 2/ δ 1亚基的表达增加所致。(c) 2004 Elsevier B.V.版权所有
We investigated the effect of chronic nicotine administration on high voltage-gated calcium channels (HVCCs) in the mouse cerebral cortex. The treatment significantly increased expression of alpha 1C, alpha 1D, alpha 1F, and alpha 2/delta 1 subunits with no changes of beta 4 subunit of L-type HVCCs. [H-3]Diltiazem binding to the particulate fractions increased with increased Bmax value. These results indicate that chronic nicotine treatment up-regulates L-type HVCCs, which is due to increased expression of alpha 1 and alpha 2/delta 1 subunits. (c) 2004 Elsevier B.V. All rights reserved.