A novel pathway for outer membrane protein biogenesis in Gram-negative bacteria.
A novel pathway for outer membrane protein biogenesis in Gram-negative bacteria.
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DOI：
10.1111/mmi.13082
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发表时间：
2015-08
影响因子：
3.6
通讯作者：
Knowles TJ
中科院分区：
文献类型：
--
作者：
Jeeves M;Knowles TJ
了解革兰氏阴性菌外膜的生物起源至关重要，因为出现了对可用抗生素产生耐药性的细菌。对于革兰氏阴性菌来说，这是一个最严重的问题，基本上很少有抗生素正在开发或可能在不久的将来可用于临床。因此，了解革兰氏阴性细菌外膜对于开发新的抗菌剂至关重要，因为该膜与外部环境直接接触，并且该膜内存在的蛋白质是微生物战争的工具，在微生物发病机制，毒力和多药耐药性中发挥关键作用。到目前为止，已经确定了一个单一的外膜复合物对于蛋白质折叠和插入外膜是必不可少的，这是β-桶组装机（BAM）复合物，在某些情况下，它由易位和组装模块（TAM）补充。在这一期的《分子微生物学》中，邓斯坦等人（Dunstan et al.）已经确定了一种新的途径，用于将整合膜蛋白的子集插入革兰氏阴性外膜中，该途径独立于BAM复合物和TAM。
The understanding of the biogenesis of the outer membrane of Gram‐negative bacteria is of critical importance due to the emergence of bacteria that are becoming resistant to available antibiotics. A problem that is most serious for Gram‐negative bacteria, with essentially few antibiotics under development or likely to be available for clinical use in the near future. The understanding of the Gram‐negative bacterial outer membrane is therefore critical to developing new antimicrobial agents, as this membrane makes direct contact with the external milieu, and the proteins present within this membrane are the instruments of microbial warfare, playing key roles in microbial pathogenesis, virulence and multidrug resistance. To date, a single outer membrane complex has been identified as essential for the folding and insertion of proteins into the outer membrane, this is the β‐barrel assembly machine (BAM) complex, which in some cases is supplemented by the Translocation and Assembly Module (TAM). In this issue of Molecular Microbiology, Dunstan et al. have identified a novel pathway for the insertion of a subset of integral membrane proteins into the Gram‐negative outer membrane that is independent of the BAM complex and TAM.