Molecular control of ciliary neuron development:: BMPs and downstream transcriptional control in the parasympathetic lineage
Molecular control of ciliary neuron development:: BMPs and downstream transcriptional control in the parasympathetic lineage
复制标题
DOI：
10.1242/dev.00165
复制
发表时间：
2002-12-01
期刊：
影响因子：
4.6
通讯作者：
Rohrer, H
中科院分区：
文献类型：
--
作者：
Müller, F;Rohrer, H
去甲肾上腺素能交感神经元的产生由BMP和下游转录因子Mash 1、Phox 2b、Phox 2a和dHand控制。我们研究了这些信号在胆碱能副交感神经元发育中的作用。Mash 1（Cash 1），Phox 2b和Phox 2a在鸡睫状神经节中的表达是由泛神经元，去甲肾上腺素能和胆碱能标记基因的顺序表达。BMP在睫状神经节形成的部位表达，并且对于睫状神经元发育是必需的和足够的。与交感神经元不同，睫状神经元不表达dHand;去甲肾上腺素能基因表达最终丢失，但可以通过异位dHand表达来维持。总之，这些结果证明了交感神经元和副交感神经睫状神经元的共同BMP依赖性，并暗示dHand在自主神经系统中维持去甲肾上腺素能基因表达。
The generation of noradrenergic sympathetic neurons is controlled by BMPs and the downstream transcription factors Mash1, Phox2b, Phox2a and dHand. We examined the role of these signals in developing cholinergic parasympathetic neurons. The expression of Mash1 (Cash1), Phox2b and Phox2a in the chick ciliary ganglion is followed by the sequential expression of panneuronal, noradrenergic and cholinergic marker genes. BMPs are expressed at the site where ciliary ganglia form and are essential and sufficient for ciliary neuron development. Unlike sympathetic neurons, ciliary neurons do not express dHand; noradrenergic gene expression is eventually lost but can be maintained by ectopic dHand expression. Together, these results demonstrate a common BMP dependence of sympathetic neurons and parasympathetic ciliary neurons and implicate dHand in the maintenance of noradrenergic gene expression in the autonomic nervous system.