A Formal Synthesis of a Muscarinic M1 Receptor Antagonist, (-)-TAN1251A
A Formal Synthesis of a Muscarinic M1 Receptor Antagonist, (-)-TAN1251A
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DOI：
10.3987/com-03-s(p)14
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发表时间：
2004
期刊：
影响因子：
0.6
通讯作者：
T. Honda;Hirotake Mizutani;Jun Takayama;Yukio Soeda
中科院分区：
文献类型：
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作者：
T. Honda;Hirotake Mizutani;Jun Takayama;Yukio Soeda
以L酪氨酸和甘氨酸为原料制备的仲胺与高价碘试剂反应生成螺环产物，再转化为合成(-)-TAN1251a的关键中间体。
An aromatic oxidation reaction of a secondary amine, prepared from L-tyrosine and glycine, with hypervalent iodine reagent gave a spirocyclic product, which was further converted into the key intermediate for the synthesis of(-)-TAN1251A.