B-lymphocyte-induced maturation protein-1 (Blimp-1) gene of torafugu (Takifugu rubripes).
B-lymphocyte-induced maturation protein-1 (Blimp-1) gene of torafugu (Takifugu rubripes).
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DOI：
10.1016/j.fsi.2005.04.007
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发表时间：
2006-03
影响因子：
4.7
通讯作者：
M. Ohtani;T. Miyadai;S. Hiroishi
中科院分区：
文献类型：
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作者：
M. Ohtani;T. Miyadai;S. Hiroishi
通过tblast搜索分析，对红鳍东方鲀B淋巴细胞诱导成熟蛋白-1（Blimp-1）基因进行同源性分析。RT-PCR和5 'RACE清楚地确定了非翻译区和编码区的序列，这是由tblast分析模糊确定的。河豚Blimp-1主要表达于淋巴器官。这些发现表明Blimp-1在鱼类B细胞向浆细胞的终末分化中起主要作用。
Homologous gene of B-lymphocyte-induced maturation protein-1 (Blimp-1) of torafugu (Takifugu rubripes) was identified by tblast search analysis. RT-PCR and 5'RACE clearly defined the sequence of the UTR and coding region which has been ambiguously determined by tblast analysis. Fugu Blimp-1 was mainly expressed in the lymphoid organs. These finding imply that Blimp-1 would take a major role in the terminal differentiation of B-cells to plasma cells in fish.