Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study
Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study
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DOI：
10.1016/s0140-6736(18)30841-9
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发表时间：
2018-04-28
期刊：
影响因子：
168.9
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Wang, Chen;Xu, Jianying;He, Jiang
背景尽管吸烟和空气污染是常见的，但目前中国成年人群中慢性阻塞性肺疾病（COPD）的患病率尚不清楚。我们进行了中国肺健康（CPH）研究，以评估COPD的患病率和危险因素在China.Methods的CPH研究是一项横断面研究，在全国代表性样本的成年人年龄在20岁或以上，从10个省，自治区，直辖市在中国大陆。所有参与者均接受了支气管扩张剂后肺功能检查。结果在2012年6月至2015年5月期间，共有57779名受试者被邀请参加研究，其中50991人（21446名男性和29545名女性）在使用支气管扩张剂后有可靠的结果，并被纳入最终分析。肺量测定定义的COPD的总体患病率为8。6%（95% CI 7 . 5-9 . 9），占99 . 9（95% CI 76 . 3-135 7)中国有100万COPD患者。男性患病率较高（11。9%，95%CI 10。2-13 . 8)女性（5）4%，4 . 6-6 . 2; p< 0 . 0001的性别差异）和40岁或以上的人（13。7%，12 . 1-15 . 5)20-39岁的人（2。1%，1 . 4-3 . 2; p< 0 . 0001年龄差异）。只有12个。0%（95% CI 8 . 1-17 . 4)的COPD患者报告了既往肺功能检查。COPD的危险因素包括20包-年或以上的吸烟暴露（比值比[OR] 1 . 95，95% CI 1。53-2 . 47），暴露于年平均直径小于2 . 5 μ m的50-74 μ g/m（3）（1 . 85，1。23-2 . 77)或75微克/立方米（3）或更高（2，00，1。36-2 .体重不足（体重指数
Background Although exposure to cigarette smoking and air pollution is common, the current prevalence of chronic obstructive pulmonary disease (COPD) is unknown in the Chinese adult population. We conducted the China Pulmonary Health (CPH) study to assess the prevalence and risk factors of COPD in China.Methods The CPH study is a cross-sectional study in a nationally representative sample of adults aged 20 years or older from ten provinces, autonomous regions, and municipalities in mainland China. All participants underwent a post-bronchodilator pulmonary function test. COPD was diagnosed according to 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.Findings Between June, 2012, and May, 2015, 57 779 individuals were invited to participate, of whom 50 991 (21 446 men and 29 545 women) had reliable post-bronchodilator results and were included in the final analysis. The overall prevalence of spirometry-defined COPD was 8 . 6% (95% CI 7 . 5-9 . 9), accounting for 99 . 9 (95% CI 76 . 3-135 . 7) million people with COPD in China. Prevalence was higher in men (11 . 9%, 95% CI 10 . 2-13 . 8) than in women (5 . 4%, 4 . 6-6 . 2; p< 0 . 0001 for sex difference) and in people aged 40 years or older (13 . 7%, 12 . 1-15 . 5) than in those aged 20-39 years (2 . 1%, 1 . 4-3 . 2; p< 0 . 0001 for age difference). Only 12 . 0% (95% CI 8 . 1-17 . 4) of people with COPD reported a previous pulmonary function test. Risk factors for COPD included smoking exposure of 20 pack-years or more (odds ratio [OR] 1 . 95, 95% CI 1 . 53-2 . 47), exposure to annual mean particulate matter with a diameter less than 2 . 5 mu m of 50-74 mu g/m(3) (1 . 85, 1 . 23-2 . 77) or 75 mu g/m(3) or higher (2 . 00, 1 . 36-2 . 92), underweight (body-mass index