Shigella Iron Acquisition Systems and their Regulation.
Shigella Iron Acquisition Systems and their Regulation.
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DOI：
10.3389/fcimb.2016.00018
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发表时间：
2016
影响因子：
5.7
通讯作者：
Murphy ER
中科院分区：
文献类型：
--
作者：
Wei Y;Murphy ER
志贺氏菌在宿主体内的存活严格依赖于病原体获得必需营养素（如铁）的能力。作为对入侵病原体的先天免疫防御，通过螯合血红素和其他宿主铁结合化合物内的元素，人类宿主内的生物可利用铁的水平维持在超低水平。志贺氏菌对螯合介导的铁限制的反应是产生多种铁摄取系统，每个系统的功能是促进利用特定宿主相关的营养铁源。作为一种平衡铁的基本需求和过量时元素毒性的机制，细菌铁获取系统的产生受到多种分子机制的严格调控。本文综述了志贺菌属细菌铁吸收系统的研究现状、分布及调控铁吸收系统的分子机制。
Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.