Biological and pharmacological roles of N6-Isopentenyladenosine:: An emerging anticancer drug
Biological and pharmacological roles of N6-Isopentenyladenosine:: An emerging anticancer drug
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DOI：
10.2174/187152008783497028
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发表时间：
2008-02-01
影响因子：
2.8
通讯作者：
Laezza, Chiara
中科院分区：
文献类型：
--
作者：
Bifulco, Maurizio;Malfitano, Anna Maria;Laezza, Chiara
真核生物和细菌tRNA的常见修饰是37位腺苷的异戊烯化，形成异戊烯基腺苷。N6-异戊烯腺苷在转录后过程中起主要作用，包括哺乳动物硒代半胱氨酸tRNA的功能。这种分子似乎具有代谢作用，由于其与类异戊二烯代谢的关系及其直接的生物活性，影响哺乳动物细胞的细胞骨架、增殖和凋亡。此外，初步临床观察似乎表明N6-异戊烯基腺苷可能用作抗癌药物。
A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6- Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary clinical observation seems to indicate a possible use of N6- Isopentenyladenosine as anticancer drug.