EFFECT OF DIGITALIS ON CENTRAL DEMYELINATIVE CONDUCTION BLOCK INVIVO
EFFECT OF DIGITALIS ON CENTRAL DEMYELINATIVE CONDUCTION BLOCK INVIVO
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DOI：
10.1002/ana.410250209
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发表时间：
1989-02-01
影响因子：
11.2
通讯作者：
SUMNER, AJ
中科院分区：
文献类型：
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作者：
KAJI, R;SUMNER, AJ
在寻找有效治疗多发性硬化症的药物时，我们研究了短效洋地黄类药物哇巴因对中枢神经系统脱髓鞘动物模型传导阻滞的影响。洋地黄特异性抑制的生电钠/钾泵负责部分静息膜电位以及高频脉冲后与活动相关的膜超极化。后者引起脱髓鞘纤维的间歇性传导阻滞。因此，洋地黄可能通过降低阻滞节点的阈值来逆转脱髓鞘性传导阻滞。在11只脊髓脱髓鞘大鼠中，在全身给予哇巴因（0.1- 0.6mg或0.21- 1.58mg/kg IP）前后，监测体感诱发电位。在所有大鼠中，通过病变的复合动作电位的传导速度减慢被显著逆转，并且未能传输高频脉冲得到改善。皮层体感诱发电位的振幅也显著增加。洋地黄是一种很有前途的治疗药物，用于多发性硬化症患者的试验。
In searching for agents effective in treating multiple sclerosis, we studied the effect of a short-acting digitalis, ouabain, on conduction block in an animal model of central nervous system demyelination. The electrogenic sodium/potassium pump, which digitalis specifically inhibits, is responsible for part of the resting membrane potential and also the activity-related membrane hyperpolarization following high-frequency impulses. The latter causes intermittent conduction block in demyelinated fibers. Therefore, digitals might be expected to reverse demyelinative conduction blocks by reducing the threshold at the blocking node. Somatosensory evoked potentials were monitored in 11 rats with spinal cord demyelination before and after systemic administration of ouabain (0.1-0.6 mg or 0.21-1.58 mg/kg IP). In all rats, slowed conduction velocity of the compound action potential through the lesion was significantly reversed, and failure to transmit high-frequency impulses was improved upon. The amplitude of the cortical somatosensory evoked potentials also increased significantly. Digitalis is a promising therapeutic agent for trial in patients with multiple sclerosis.