INCREASED CONCENTRATIONS OF NONESTERIFIED ARACHIDONIC-ACID, 12L-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID, PROSTAGLANDIN-E2, AND PROSTAGLANDIN-F2ALPHA IN EPIDERMIS OF PSORIASIS
INCREASED CONCENTRATIONS OF NONESTERIFIED ARACHIDONIC-ACID, 12L-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID, PROSTAGLANDIN-E2, AND PROSTAGLANDIN-F2ALPHA IN EPIDERMIS OF PSORIASIS
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DOI：
10.1073/pnas.72.12.5130
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发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
VOORHEES, JJ
中科院分区：
文献类型：
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作者：
HAMMARSTROM, S;HAMBERG, M;VOORHEES, JJ
银屑病病变表皮的环 AMP/环 GMP 比率可能降低。这种比例的改变可能部分是造成病变表皮特征性糖原储存、细胞快速增殖和分化减少的原因。使用氘标记载体和多离子分析测量银屑病未受累和受累表皮标本中前列腺素 E2 和 F2α、游离花生四烯酸和 12L-羟基-5,8,10,14-二十碳四烯酸的浓度。速冻标本含有：未受累表皮中花生四烯酸的含量为 1.4 +/- 0.4 微克/克（湿重），而受累表皮中的花生四烯酸含量为 36.3 +/- 16.7 微克/克（P = 0.015）；未受累表皮中羟基二十碳四烯酸含量低于 0.05 +/- 0.01 微克/克，而受累表皮中羟基二十碳四烯酸含量为 4.1 +/- 1.9 微克/克（P = 0.015）；未受累表皮中前列腺素 E2 为 23.6 +/- 5.0 ng/g，而受累表皮中前列腺素 E2 为 33.1 +/- 5.7 ng/g（P 小于 0.01）；未受累表皮中前列腺素 F2α 为 21.0 +/- 4.4 ng/g，而受累表皮中前列腺素 F2α 为 39.0 +/- 5.9 ng/g（P 小于 0.01）。受累表皮中的花生四烯酸和羟基二十碳四烯酸水平密切相关（r = 0.97）。受累表皮中花生四烯酸和 12L-羟基-5,8,10,14-二十碳四烯酸水平的增加可能具有诊断和病理生理学的重要性。
Lesional epidermis of psoriasis has a probable reduction in the cyclic AMP/cyclic GMP ratio. This altered ratio may in part be responsible for the characteristic glycogen storage, rapid cell proliferation, and reduced differentiation in lesional epidermis. The concentrations of prostaglandins E2 and F2alpha, free arachidonic acid, and 12L-hydroxy-5,8,10,14-eicosatetrawnoic acid in specimens of uninvolved and involved epidermis of psoriasis were measured with deuterium-labeled carriers and multiple ion analysis. Snap frozen specimens contained: 1.4 +/- 0.4 mug/g (wet weight) of arachidonic acid in uninvolved in contrast to 36.3 +/- 16.7 mug/g in involved epidermis (P = 0.015); less than 0.05 +/- 0.01 mug/g of hydroxyeicosatetraenoic acid in uninvolved in contrast to 4.1 +/- 1.9 mug/g in involved epidermis (P = 0.015); 23.6 +/- 5.0 ng/g of prostaglandin E2 in uninvolved in contrast to 33.1 +/- 5.7 ng/g in involved epidermis (P less than 0.01); and 21.0 +/- 4.4 ng/g of prostaglandin F2alpha in uninvolved in contrast to 39.0 +/- 5.9 ng/g in involved epidermis (P less than 0.01). The arachidonic acid and hydroxyeicosatetraenoic acid levels in involved epidermis were strongly correlated (r = 0.97). The increased levels of arachidonic acid and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid in involved epidermis may have diagnostic and pathophysiological importance.