COMPARISON OF CONTRACTILE STATE AND MYOSIN ISOZYMES OF RAT RIGHT AND LEFT-VENTRICULAR MYOCARDIUM
COMPARISON OF CONTRACTILE STATE AND MYOSIN ISOZYMES OF RAT RIGHT AND LEFT-VENTRICULAR MYOCARDIUM
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DOI：
10.1016/s0022-2828(87)80395-4
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发表时间：
1987-05-01
影响因子：
5
通讯作者：
ALLEN, PD
中科院分区：
文献类型：
--
作者：
BROOKS, WW;BING, OHL;ALLEN, PD
我们比较了成年(6月至8月龄)雄性大鼠右、左心室乳头肌的心肌力学和肌球蛋白同工酶。力-速度关系分析表明，在轻负荷时，右室乳头肌收缩速度比左室快(2.68±-)。0.13比2.18。+-。0.07肌长/S在刺激后测量75ms，0.5g/mm2；P<；0.01)。右室乳头肌中α的含量显著增加。含有V1肌球蛋白同工酶的重链和较少的含有β-β的V3。重链肌球蛋白同工酶高于左心室标本(P<；0.05)。乳头肌和心室游离壁肌球蛋白同工酶在各自的腔室内分布没有显著差异。存在相对较大比例的α。右室乳头肌的重链肌球蛋白同工酶(V1)与右室乳头肌的收缩速度显著相关(r=0.60；P<；0.01)。
We compared myocardial mechanics and myosin isozymes of right and left ventricular papillary muscles from adult (6 to 8 month old) male rats. Analysis of force velocity relations indicate that right ventricular papillary muscles contract more raidly than left at light loads (2.68 .+-. 0.13 vs 2.18 .+-. 0.07 muscle length/s measured 75 ms following stimulation, at 0.5 g/mm2; P < 0.01). Right ventricular papillary muscles had significantly more of the .alpha. heavy chain containing V1 myosin isozyme and less of the V3 containing .beta. heavy chain myosin isozyme than left ventricular preparations (P < 0.05). Papillary muscle and ventricular free wall myosin isozyme distribution were not significantly different within their respective chambers. The presence of a relatively larger proportion of the .alpha. heavy chain containing myosin isozyme (V1) in right ventricle papillary muscles relative to left correlated with the more rapid velocities of shortening seen in right ventricular papillary muscles (r = 0.60; P < 0.01).