Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin
Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin
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DOI：
10.1016/j.virol.2008.03.036
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发表时间：
2008-07-05
期刊：
影响因子：
3.7
通讯作者：
Takada, Ayato
中科院分区：
文献类型：
--
作者：
Igarashi, Manabu;Ito, Kimihito;Takada, Ayato
在流感病毒血凝素(HA)中添加低聚糖侧链被认为有助于人类群体中病毒逃避免疫压力。为了确定获得N-连锁糖基化的隐含潜力，我们分析了16种亚型禽流感病毒的遗传背景，其中一些可能是未来可能的大流行病毒。我们发现，不同的HA亚型在产生N-糖基化位点的基因组序列上存在显著差异。值得注意的是，最近流行的H5和H9亚型禽流感病毒可能比过去的大流行病毒具有更强的能力经历与HA糖基化相关的突变。我们假设，保存在天然水库中的流感病毒如果被引入人类群体，根据其HA亚型的不同，可能具有不同的持续传播潜力。(C)2008 Elsevier Inc.保留所有权利。
The addition of oligosaccharide side chains to influenza virus hemagglutinin (HA) is believed to facilitate viral escape from immune pressure in the human population. To determine the implicit potentials for acquisition of N-linked glycosylation, we analyzed the genetic background of 16 subtypes of avian influenza virus, some of which may be potential pandemic viruses in the future. We found a significant difference among HA subtypes in their genomic sequences to produce N-glycosylation sites. Notably, recently circulating avian influenza viruses of the H5 and H9 subtypes may have rather greater capacities to undergo mutations associated with glycosylation of HA than past pandemic viruses. We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population. (C) 2008 Elsevier Inc. All rights reserved.