MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits
MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits
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DOI：
10.1096/fj.10-169599
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发表时间：
2011-02-01
期刊：
影响因子：
4.8
通讯作者：
Serhan, Charles N.
中科院分区：
文献类型：
--
作者：
Recchiuti, Antonio;Krishnamoorthy, Sriram;Serhan, Charles N.
控制急性炎症消退的机制受到广泛关注。在这里，我们研究了自限性急性炎性渗出物中的microRNAs（miRNAs）及其通过resolvin D1（RvD 1）的调节。利用实时荧光定量PCR分析，我们发现，在解决渗出物中，miR-21、miR-146 b、miR-208 a、miR-203、miR-142、miR-302 d和miR-219被选择性调节（P
Mechanisms controlling resolution of acute inflammation are of wide interest. Here, we investigated microRNAs (miRNAs) in self-limited acute inflammatory exudates and their regulation by resolvin D1 (RvD1). Using real-time PCR analysis, we found in resolving exudates that miR-21, miR-146b, miR-208a, miR-203, miR-142, miR-302d, and miR-219 were selectively regulated (P