Development of a cellulose-based hydrogel with glucose-lowering, ROS-scavenging, and colorimetric detection properties
Development of a cellulose-based hydrogel with glucose-lowering, ROS-scavenging, and colorimetric detection properties
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DOI：
10.1007/s10570-023-05509-w
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发表时间：
2023-09
期刊：
影响因子：
5.7
通讯作者：
Yan Gao;Yuangong Zhang;Yu Wang;Bing Liu;Feng Liu;Xinwu Ba
中科院分区：
文献类型：
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作者：
Yan Gao;Yuangong Zhang;Yu Wang;Bing Liu;Feng Liu;Xinwu Ba
本文合成了一种基于纤维素的水凝胶，它具有降低血糖水平、清除活性氧自由基(ROS)和比色监测早期损伤的能力，以解决伤口表面葡萄糖和过氧化氢过度表达的问题。简单地说，以含酚邻苯二甲酸硼酸酯(BAPE-PPH)为交联剂，与羟丙基甲基纤维素(HPMC)反应，制备了具有良好生物相容性的水凝胶(HPMC@PPH-HS)。由于葡萄糖对苯基硼酸酯基团的亲和力高于纤维素衍生物，因此HPMC@PPH-HS表现出优异的降糖性能。网络中B-C键的存在使所获得的水凝胶具有H_2O_2敏感性，B-C键的断裂迫使BAPE-PPH部分转变为PPH，从而引起比色行为。因此，所获得的HPMC@PPH-HS为丰富智能水凝胶家族提供了信息，并且其在糖尿病伤口愈合中的潜在应用可能是可取的。
In this paper, a cellulose-based hydrogel with the ability to lower glucose levels, scavenge reactive oxygen species (ROS), and colorimetrically monitor early lesions was synthesized to address the issue of glucose and H2O2overexpression on the wound surface. Briefly, boronic acid pinacol ester containing phenolphthalein (BAPE-PPH) was employed as a crosslinker to react with hydroxypropyl methylcellulose (HPMC) to afford hydrogels (HPMC@PPH-Hs) with good biocompatibility. Because glucose has higher affinity for the phenylboronic ester group than cellulose derivatives, the HPMC@PPH-Hs showed excellent glucose-lowering performance. The presence of B-C bonds in the network endows the as-obtained hydrogel with H2O2sensitivity, and cleavage of the B-C bonds forces the transformation of BAPE-PPH moieties into PPH, giving rise to colorimetric behaviour. Thus, the obtained HPMC@PPH-Hs provide information to enrich the family of smart hydrogels, and its potential application in diabetic wound healing may be desirable.Graphical abstract