Adenosine: an old drug newly discovered.
Adenosine: an old drug newly discovered.
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DOI：
10.1097/aln.0b013e3181b060f2
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发表时间：
2009-10
期刊：
影响因子：
8.8
通讯作者：
Eltzschig HK
中科院分区：
文献类型：
--
作者：
Eltzschig HK
几十年来，麻醉医师一直使用静脉注射腺苷作为诊断或治疗围手术期室上性心动过速的主要疗法。最近，特异性腺苷受体治疗剂或细胞外腺苷产生或单个腺苷受体缺陷的基因靶向小鼠变得可用。这些模型使医生和科学家能够更多地了解细胞外核苷酸代谢和腺苷信号传导的生物学功能。这些功能包括通过许多哺乳动物组织（例如血管内皮细胞、肌细胞、肝细胞、肠上皮细胞或免疫细胞）表达的腺苷受体的特异性信号传导作用。目前，调节细胞外腺苷信号传导的药理学方法被评估其在围手术期医学中的潜在用途，包括减轻急性肺损伤、肾、肠、肝和心肌缺血或血管渗漏。如果这些实验室研究可以转化为临床实践，腺苷受体为基础的治疗可能成为日常麻醉实践的一个不可分割的药理学组成部分。
Over decades, anesthesiologists have used intravenous adenosine as mainstay therapy for diagnosing or treating supraventricular tachycardia in the perioperative setting. More recently, specific adenosine receptor therapeutics or gene-targeted mice deficient in extracellular adenosine production or individual adenosine receptors became available. These models enabled physicians and scientists to learn more about the biological functions of extracellular nucleotide metabolism and adenosine signaling. Such functions include specific signaling effects through adenosine receptors expressed by many mammalian tissues, for example vascular endothelia, myocytes, heptocytes, intestinal epithelia or immune cells. At present, pharmacological approaches to modulate extracellular adenosine signaling are evaluated for their potential use in perioperative medicine, including attenuation of acute lung injury, renal, intestinal, hepatic and myocardial ischemia, or vascular leakage. If these laboratory studies can be translated into clinical practice, adenosine receptor based therapeutics may become an integral pharmacological component of daily anesthesiology practice.