Alpha frequency rTMS modulates theta lagged nonlinear connectivity in dorsal attention network
Alpha frequency rTMS modulates theta lagged nonlinear connectivity in dorsal attention network
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DOI：
10.1016/j.brainresbull.2020.06.018
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发表时间：
2020-09-01
影响因子：
3.8
通讯作者：
Ikeda, Shunichiro
中科院分区：
文献类型：
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作者：
Kazemi, Reza;Rostami, Reza;Ikeda, Shunichiro
背外侧前额叶皮层（DLPFC）是背侧注意网络（DAN）的关键结构，通过调节大脑中与任务相关和不相关区域的活动来促进持续注意。α和θ频带增强了注意力网络不同部分之间的连接，而这些连接是由θ和α频带中的长程非线性连接促进的。本研究旨在探讨α和θ频率重复经颅磁刺激（rTMS）对RDLPFC的行为和电生理效应。20名健康受试者被随机分配到两组theta（n = 11，f = 6 Hz）和alpha（n = 9，f = 10 Hz）rTMS。在每次训练前后记录休息和执行任务时的脑电图（EEG）。计算DAN和默认模式网络（DMN）的电流源密度（CSD）和功能连接性（FC），并分析它们与快速视觉信息处理任务（RVIP）评分的相关性。α频率rTMS导致RVIP评分的显著变化。主动theta rTMS引起中央后回CSD增加，主动alpha rTMS引起顶下小叶CSD显著改变。Theta滞后的非线性连接受到α rTMS的干扰，在DAN和DMN中观察到FC变化。在α rTMS组中，DAN区域与RVIP评分之间呈正相关。左侧aPFC和左侧DLPFC中θ频带的活动增加与RVIP中较高的总命中呈正相关。这项研究首次表明，θ和α频率rTMS能够以一种在持续注意力任务中获得更好表现的方式调节DAN和DMN中的FC。
Dorsolateral prefrontal cortex (DLPFC) is a key structure in dorsal attention network (DAN) that facilitates sustained attention by modulating activity in task related and unrelated regions of the brain. Alpha and theta frequency bands enhance connectivity among different parts of the attention network and these connections are facilitated by long-range nonlinear connectivity in theta and alpha frequency bands. This study is an investigation of the behavioral and electrophysiological effects of alpha and theta frequency repetitive transcranial magnetic stimulation (rTMS) over RDLPFC. 20 healthy participants were randomly assigned to two groups of theta (n = 11, f = 6 Hz) and alpha (n = 9, f = 10 Hz) rTMS. Electroencephalogram (EEG) was recorded before and after each session while resting and performing tasks. Current source density (CSD) and functional connectivity (FC) in DAN and default mode network (DMN) and their correlations with rapid visual information processing task (RVIP) scores were calculated. Alpha frequency rTMS resulted in significant changes in RVIP scores. Active theta rTMS caused an increase in CSD in Postcentral gyrus and active alpha rTMS resulted in significant CSD changes in inferior parietal lobule (IPL). Theta lagged nonlinear connectivity was mudulated by alpha rTMSand FC changes were observed in DAN and DMN. Positive correlations were observed between DAN regions and RVIP scores in the alpha rTMS group. Increased activity in theta frequency band in left aPFC and left DLPFC correlated positively with higher total hits in RVIP. This study showed for the first time that theta and alpha frequency rTMS are able to modulate FC in DAN and DMN in a way that results in better performance in a sustained attention task.