Porcine acute phase protein concentrations in different diseases in field conditions
Porcine acute phase protein concentrations in different diseases in field conditions
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DOI：
10.1111/j.1439-0450.2006.01002.x
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发表时间：
2006-12-01
期刊：
影响因子：
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通讯作者：
Ceron, J. J.
中科院分区：
文献类型：
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作者：
Parra, M. D.;Fuentes, P.;Ceron, J. J.
在自然发生的猪繁殖与呼吸综合征病毒（PRRSV）、Aujeszky病病毒（ADV）、猪圆环病毒2型（PCV 2）和猪肺炎支原体（Mycoplasma hyoprotein）感染的猪中，以及在尾部和耳部咬伤的动物中，测定了5种急性时相蛋白（APP）[C-反应蛋白（CRP）、血清淀粉样蛋白A（SAA）、触珠蛋白（Hp）、猪MAP和白蛋白]。关节炎和其他急性炎症过程。健康的无特定病原体（SPF）猪用作对照。在PRRSV感染的猪中，与对照组相比，除猪MAP外，所有APP均表现出显著变化。在受ADV感染的动物中，只有Hp出现统计学显著性变化，而受PCV 2感染的猪在所有检测的APP中均显示出显著变化。感染支原体病的动物显示所有阳性APP的浓度显著高于SPF猪的水平，但白蛋白浓度与对照组无差异。最后，所有研究的APPS在急性炎症猪中均显示出实质性变化。结果表明，在所研究的不同疾病中产生了急性期反应，这种反应在具有临床体征和并发细菌过程的动物中更高。触珠蛋白是更好地反映病理状态的APP;然而，为了获得更完整和有价值的信息，可能建议进行包括另一APP（如CRP或SAA）的APPS谱。
Five acute phase proteins (APPs) [C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), pig-MAP and albumin] were measured in pigs with naturally occurring infections by porcine reproductive and respiratory syndrome virus (PRRSV), Aujeszky's disease virus (ADV), porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae, and in animals with tail and ear bites, arthritis and other acute inflammatory processes. Healthy specific pathogen-free (SPF) pigs were used as controls. In PRRSV-infected pigs, all APPs with the exception of pig-MAP exhibited significant changes compared with controls. In animals affected with ADV only Hp presented changes of statistical significance, whereas pigs with PCV2 showed marked modifications in all APPs tested. Animals affected with Mycoplasmosis showed concentrations of all positive APPs significantly above levels obtained in SPF pigs, though albumin concentrations did not differ from controls. Finally, all APPS studied showed substantial changes in pigs with acute inflammation. The results indicated that an acute phase response was developed in the different diseases studied, this response being higher in animals with clinical signs and concurrent bacterial processes. Haptoglobin would be the APP that better reflects pathological states; however, to get more complete and valuable information it might be advisable to perform APPS profiles including another APP, such as CRP or SAA.