Association of Lean Body Mass Index and Peritoneal Protein Clearance in Peritoneal Dialysis
Association of Lean Body Mass Index and Peritoneal Protein Clearance in Peritoneal Dialysis
复制标题
腹膜透析中去脂体重指数与腹膜蛋白清除率的关系
DOI：
10.1159/000498841
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发表时间：
2019-01-01
影响因子：
2.8
通讯作者：
Yang, Xiao
中科院分区：
文献类型：
--
作者：
Fan, Jinjin;Ye, Hongjian;Yang, Xiao
背景/目的：腹膜透析（PD）人群的腹膜蛋白清除率（PPCl）与营养状况之间的关系尚未明确。本研究旨在探讨PPCl与PD人群营养状况的关系。方法：对2013年4月至11月单中心的帕金森病患病患者进行横断面调查，计算透析液中蛋白质丢失总量。 PPC1反映腹膜蛋白丢失的个体差异，计算公式为：PPC1(ml/天)=24小时透析液蛋白丢失/(白蛋白/0.4783)。通过多频生物电阻抗分析（BIA）评估通过去脂体重指数（LBMI）测量的营养状况。结果：共纳入 351 名 PD 患者（55% 为男性，17.1% 患有糖尿病，平均年龄 47.7 +/- 14.3 岁）。中位 PPC1 为 58 毫升/天。根据 PPC1 四分位数将患者分为四组进行比较。与较低 PPCl 四分位数相比，较高 PPCl 患者的体重指数 (BMI) 较高 (P
Background/Aims: The relationship between peritoneal protein clearance (PPCl) and nutritional status in peritoneal dialysis (PD) population have not been clarified. This study aims to investigate the relationship between PPCl and nutritional status in PD population. Methods: Prevalent PD patients were enrolled in the cross-sectional survey in a single center from April to November 2013. The total amount of protein loss in the dialysate was calculated. PPCl reflects the individual differences of peritoneal protein loss, and is calculated by the formula, that PPCl (ml/day) = 24-h dialysate protein loss / (albumin/0.4783). Nutritional status measured by lean body mass index (LBMI) was assessed by multi-frequency bioelectrical impedance analysis (BIA). Results: Totally 351 PD patients (55% male, 17.1% with diabetes, mean age 47.7 +/- 14.3 years) were included. The median PPCl was 58 ml/day. Patients were divided into four groups for comparison according to the PPCl quartiles. Compared with lower PPCl quartiles, patients with higher PPCl had higher body mass index (BMI) (P