Endoscopic Evaluation of Crohn's Disease Activity: Comparison of the CDEIS and the SES-CD
Endoscopic Evaluation of Crohn's Disease Activity: Comparison of the CDEIS and the SES-CD
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DOI：
10.1002/ibd.21300
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发表时间：
2010-12-01
影响因子：
4.9
通讯作者：
Farkkila, Martti
中科院分区：
文献类型：
--
作者：
Sipponen, Taina;Nuutinen, Hannu;Farkkila, Martti
背景：对克罗恩病（CD）、克罗恩病严重程度指数（CDEIS）和克罗恩病简单内镜评分（SES-CD）进行前瞻性平行评分的数据很少。方法：在一项横断面研究中，86例转介回肠结肠镜检查的CD患者每次内镜检查后立即进行CDEIS和SES-D评分。此外，在CD治疗后，32例CD患者接受了随访的内窥镜检查，并进行了CDEIS和SES-CD评分。内镜评分分为不活跃、轻度、中度和重度。采用克罗恩病活动性指数（CDAI）评估临床活动性，并测定血清c反应蛋白（CRP）。结果：SES-CD与CDEIS相关性显著（Spearman’s r = 0.938, P < 0.0001）。SES-CD与CDAI （r = 0.473）或CRP （r = 0.525，均P < 0.0001）相关性较弱。SES-CD从无活性到严重的分级与CDEIS的分级显著相关（r = 0.859, P < 0.0001）。基线和随访内窥镜评分之间的变化具有显著相关性（δ - cdeis和δ - ses - cd之间r = 0.828, P < 0.001），但与δ - cdai或δ - crp没有相关性（P均为0.05）。结论：两种有效的内镜评分，CDEIS和SES-CD，以及它们在CD治疗期间的变化显示出密切的相关性。对于临床常规的内镜活动评分，SES-CD可以替代CDEIS。
Background: Few data exist of prospective parallel scoring of the validated endoscopic scores in Crohn's disease (CD), Crohn's Disease Index of Severity (CDEIS), and Simple Endoscopic Score for Crohn's Disease (SES-CD).Methods: Both the CDEIS and the SES-D were scored immediately after each endoscopy of 86 CD patients referred for ileocolonoscopy in a cross-sectional study. Furthermore, after CD therapy, 32 CD patients underwent a follow-up endoscopy with scoring of the CDEIS and SES-CD. Endoscopic scorings were graded as inactive, mild, moderate, or severe. Clinical activity was assessed with the Crohn's Disease Activity Index (CDAI) and serum C-reactive protein (CRP) was measured.Results: The SES-CD correlated with the CDEIS significantly (Spearman's r = 0.938, P < 0.0001). Weaker correlations were detected between the SES-CD and the CDAI (r = 0.473) or CRP (r = 0.525, both P < 0.0001). Grading of SES-CD from inactive to severe correlated significantly with grading of the CDEIS (r = 0.859, P < 0.0001). Changes between baseline and follow-up endoscopy scores correlated significantly (r = 0.828 between delta-CDEIS and delta-SES-CD, P < 0.001), but failed to correlate with delta-CDAI or delta-CRP (all P > 0.05).Conclusions: Both validated endoscopic scores, the CDEIS and SES-CD, and their changes during CD therapy demonstrated a close correlation. For scoring of endoscopic activity in clinical routine, the SES-CD could replace the CDEIS.