Prognostic value of FOXP3(+) regulatory T cells in patients with diffuse large B-cell lymphoma: a systematic review and meta-analysis.
Prognostic value of FOXP3(+) regulatory T cells in patients with diffuse large B-cell lymphoma: a systematic review and meta-analysis.
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FOXP3 调节性 T 细胞对弥漫性大 B 细胞淋巴瘤患者的预后价值：系统评价和荟萃分析
DOI：
10.1136/bmjopen-2021-060659
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发表时间：
2022-09-06
期刊：
影响因子：
2.9
通讯作者：
Zhang, Min
中科院分区：
文献类型：
--
作者：
Bai, Yuping;He, Tingting;Zhang, Liyan;Liu, Qianqian;Yang, Jing;Zhao, Ziru;Yang, Kehu;Zhang, Min
We aimed to comprehensively evaluate the relationship between forkhead box P3 (FOXP3+) regulatory T cell (Treg) expression and diffuse large B-cell lymphoma (DLBCL) prognosis and to explore the sources of heterogeneity of the results. Systematic review and meta-analysis. We searched the Cochrane Library, PubMed, Embase and Web of Science databases up to 5 December 2021. We included studies that analysed the prognostic significance of FOXP3+ Tregs in DLBCL. We included studies reported in Chinese or English that reported HRs and related 95% CIs for prognosis. We extracted data from eligible studies. HRs and 95% CIs were used to assess the prognostic value. Fourteen eligible studies were identified. FOXP3+ Treg expression was not associated with overall survival (OS) (HR=0.72, 95% CI 0.45 to 1.16) or progression-free survival (HR=0.86, 95% CI 0.54 to 1.38). The three approaches used to measure FOXP3+ Treg expression (pinteraction<0.001) may be the source of the heterogeneity of the results. Subgroup analysis found that a higher expression of FOXP3+ Tregs was associated with better OS in all populations and in Asians when FOXP3+ Treg expression was measured by the number of positive cells (HR=0.36 (95% CI 0.22 to 0.58) in the former, HR=0.33 (95% CI 0.20 to 0.55) in the latter) or the percentage of positive cells (HR=0.49 (95% CI 0.27 to 0.89) in the former, HR=0.38 (95% CI 0.21 to 0.70) in the latter). However, when measured by the score, inverse results were found (HR=1.56, 95% CI 1.01 to 2.42). Approaches to measuring FOXP3+ Treg expression might be the major source of heterogeneity in studies of the prognostic significance of FOXP3+ Tregs in DLBCL. FOXP3+ Treg expression might be used to predict the prognosis of patients with DLBCL when FOXP3+ Treg expression is calculated by the number or the percentage of positive cells, especially in Asian populations.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
2.6
作者：
Nam, Soo Jeong;Go, Heounjeong;Jeon, Yoon Kyung
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Jeon, Yoon Kyung
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7.2
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Nam SJ;Kim S;Kwon D;Kim H;Kim S;Lee E;Kim TM;Heo DS;Park SH;Lim MS;Kim CW;Jeon YK
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Jeon YK
影响因子：
2.5
作者：
Tierney JF;Stewart LA;Ghersi D;Burdett S;Sydes MR
通讯作者：
Sydes MR
影响因子：
10.1
作者：
Tzankov, Alexandar;Meier, Cecile;Dirnhofer, Stephan
通讯作者：
Dirnhofer, Stephan