Chemokines as mediators of tumor angiogenesis and neovascularization.

Chemokines as mediators of tumor angiogenesis and neovascularization.
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DOI:
10.1016/j.yexcr.2010.10.020
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发表时间:
2011-03-10
影响因子:
3.7
通讯作者:
Strieter RM
Strieter RM
中科院分区:
医学3区
文献类型:
--
作者:
Keeley EC;Mehrad B;Strieter RM

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趋化因子是一个结构上同源的肝素结合蛋白超家族,影响肿瘤的生长和转移。CXC和CC趋化因子家族的几个成员是新血管形成的有效诱导者,而CXC趋化因子的一个子集是有效的抑制因子。本文就趋化因子在肿瘤血管生成和新生血管中的作用作一综述。
Chemokines are a superfamily of structurally homologous heparin-binding proteins that influence tumor growth and metastasis. Several members of the CXC and CC chemokine families are potent inducers of neovascularization, whereas a subset of the CXC chemokines are potent inhibitors. In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization.
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