[Minimally invasive cytoselective radiation therapy using boron neutron capture reaction].
[Minimally invasive cytoselective radiation therapy using boron neutron capture reaction].
复制标题
利用硼中子俘获反应的微创细胞选择性放射治疗。
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Hiroyuki Nakamura
中科院分区：
文献类型：
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作者：
Hiroyuki Nakamura
硼中子俘获治疗（BNCT）的细胞杀伤效应是由于两种基本无毒的物质硼-10（（10）B）和热中子的核反应，其破坏作用在硼负载的组织中被充分观察到。硼在肿瘤组织中的高积累和选择性递送是实现癌症的有效中子捕获治疗的最重要要求。本文综述了脂质体硼给药系统（BDS）作为一种新的有前途的方法，满足这些要求的BNCT。BDS涉及两种策略：（1）将硼包封在脂质体的水性核心中和（2）将硼积累在脂质体双层中。本文综述了近年来硼脂质体给药系统的研究进展。
The cell-killing effect of boron neutron capture therapy (BNCT) is due to the nuclear reaction of two essentially nontoxic species, boron-10 ((10)B) and thermal neutrons, whose destructive effect is well observed in boron-loaded tissues. High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve efficient neutron capture therapy of cancers. This review focuses on liposomal boron delivery system (BDS) as a recent promising approach that meet these requirements for BNCT. BDS involves two strategies: (1) encapsulation of boron in the aqueous core of liposomes and (2) accumulation of boron in the liposomal bilayer. In this review, recent development of liposomal boron delivery system is summarized.
影响因子：
4.7
作者：
Pan, XQ;Wang, HQ;Lee, RJ
通讯作者：
Lee, RJ